Antibiotic Therapy Peak and Trough
The principle of antibiotic therapy peak and through is a pharmacokinetic property of any drug. It determines the liberation, absorption, distribution, metabolism and excretion of the antibiotic. This deals with the mean inhibitory concentration (MIC) level of any antibiotic to inhibit intravascular bacterial species propagation throughout the body. The peak refers to the highest point of drug concentration in the blood after liberation and absorption to the body occurs. The trough refers to the lowest point of drug concentration in the blood after metabolism and excretion from the body occurs. Thus, the mean inhibitory concentration (MIC) level is necessary to be maintain throughout the therapy period to prevent recurrences of blood borne bacterial species.
Posted by liciniolopez on 9/4/2009
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Factors associated with otoxicity include increasing age, duration of therapy, elevated peak and trough levels, concurrent loop diuretics or vancomycin, underlying disease states and previous exposure to aminoglycosides. ... A PK/PD Approach to Antibiotic Therapy...
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A PK/PD Approach to Antibiotic Therapy ... PK parameters quantify the serum level time course of an antibiotic. The three pharmacokinetic parameters that are most important for evaluating antibiotic efficacy are the peak serum level (Cmax), the trough level (Cmin), and the Area Under the serum concentration time Curve (AUC).
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(c) Current antibiotic therapy; (d) Infectious diagnosis; (e) Renal and hepatic function; ... concomitant drug therapy, and hydration status. When to draw levels: ; Aminoglycoside: Peak/trough: 30 minutes before and after a 30 minute infusion. Vancomycin: Peak: 60 minutes after the infusion.
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Other POC-IT Resources ... POC-IT Center; HIV Guide; ... JH Infection Control; Center for Clinical Global Health; JH Viral Hepatitis Center; JH Center for Global Health; JH Division of Infectious Diseases; Infectious Diseases Grand Rounds; Zambia HIV Guide;
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The effect of dosage and the relative importance of peak and trough concentrations in serum ... Carbon C. Evaluation of antibiotic diffusion into cardiac vegetations by ... Value of serum tests in combined drug therapy of endocarditis. ...
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The practice of routine therapeutic drug monitoring originated when the guidelines for monitoring peak and trough concentrations of aminoglycosides were applied to vancomycin therapy, based on similarities in pharmacokinetic ... Geraci JE, Heilman FR, Nichols DR, Wellman WE. Antibiotic therapy of bacterial endocarditis.
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Segreti J, Trenholme GM, Levin S. Antibiotic therapy in the allergic patient. Med Clin North Am 1995;79:935-942 ... Traditionally, clinicians have monitored peak and trough serum aminoglycoside concentrations in an effort to limit the risk of adverse reactions and to achieve optimum therapeutic response.
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antibiotic generic cephalexin silver hospital protocol prophylaxis pediatric antibiotic antibiotic resistance in staph antibiotic alternative antibiotic advisory team prescription online and antibiotic antibiotic use steriod interaction excema what is antibiotic resistance sanford antibiotic guide ;
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If we accept the reasonable idea, so far unproven in humans, that the AUC predicts ototoxicity more closely than peak and trough levels, then a group that would be expected to have more ototoxicity than the norm are individuals with poor kidney function.
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