Peak and Trough Blood Levels
Peak and trough blood levels refer to a drug test administered to check a certain level of drug in a person's system. The "trough" level refers to the level of medication in a persons system right before the next dose of medication is needed. It is the lowest level of medication possible in the system. The "peak" level refers to the amount of medication in a person systems approximately half and hour after the medication. It is the highest level of medication possible in the system.
Posted by RainaRosa on 9/4/2009
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Treatment of a single positive blood culture for coagulase negative staphylococci ... It is unclear whether elevated trough or peak levels are responsible for ototoxicity. Data in the literature suggest that trough levels of 13 to 32 mcg/ml and peak levels of 21 to 62 mcg/ml are associated with this adverse effect.
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This is a question about drug concentration in human blood system. Can someone clarify for me what is meant by PEAK and TROUGH concerning drug levels in the ...
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Although the patients were prescribed dosages presumed adequate to achieve therapeutic levels of drug(s), the investigators found large interindividual differences in peak and trough blood levels.
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Because Gentamicin's kinetics are so simple, we can produce useful simulations of blood levels using a simple Excel spreadsheet. All one has ... If we accept the reasonable idea, so far unproven in humans, that the AUC predicts ototoxicity more closely than peak and trough levels, then a group that would be expected to have...
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Cyclosporine trough levels and peak cyclosporine blood levels were correlated with the calculated area under the curve. Cyclosporine trough levels were monitored in equal numbers of matched controls.
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Expert articles, personal stories, blogs, Q&A, news, local resources, pictures, video and a supportive community. Peak And Trough Blood Levels - Health Knowledge Made Personal. ... Members related to peak and trough blood levels...
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Trough blood levels were monitored daily during the hospital stay by immunoassay. Liver biopsies were routinely performed at day 7 posttransplantation. The tissue assay was developed by liquid chromatography-mass spectrometry.
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