A class of chemical compounds comprising fatty acid ester derivatives used to The patent also states that the compounds inhibit beta-lactamase enzymes.
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www.freepatentsonline.com/5633245.html
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The enzymes of the -lactamase family of gram-negative bacteria play a significant role in the development of resistance to -lactam antibiotics. 1987. XL1-Blue: a high efficiency plasmid transforming recA Escherichia coli strain with beta-galactosidase selection. Bio Techniques 5:376-378.
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aac.asm.org/cgi/content/full/42/6/1323
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The following ß-lactams were tested: ampicillin (Sigma Chemical Co., Substrate profile of ADC-7 ß-lactamase. The substrate profile of ADC-7 ß-lactamase closely resembled other AmpC ß-enzymes found in Acinetobacter spp. (30) (Table 4). Narrow-spectrum cephalosporins were the most efficiently hydrolyzed substrates.
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aac.asm.org/cgi/content/full/49/7/2941
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This is usually brought about through the use of competitive chemical analogs for It inhibits beta lactamase enzymes and has given extended life to...
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www.textbookofbacteriology.net/antimicrobial_3.html
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The beta-lactam antibiotics bind to and inhibit enzymes needed for the synthesis of the peptidoglycan wall. Cycloserine inhibits synthesis of the bacterial cell wall but by a different mechanism than the beta-lactam antibiotics discussed above. Cycloserine is an analog of D-alanine and blocks the incorporation of D...
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users.rcn.com/jkimball.ma.ultranet/BiologyPages/A/Antib...
users.rcn.com/jkimball.ma.ultranet/BiologyPages/A/Antibiotics.html
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Clavulanate does not inhibit beta-lactamases such as the Richmond-Sykes type I enzymes Chemical Phenomena; Chemistry; Drug Resistance, Microbial; Enzyme
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www.ncbi.nlm.nih.gov/pubmed/3907341
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As all catalysts, enzymes do not alter the position of the chemical .... which inhibits the COX-1 and COX-2 enzymes that produce the inflammation messenger to antibiotics such as penicillin because enzymes called beta-lactamases are...
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en.wikipedia.org/wiki/Enzyme
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Control of growth usually involves the use of physical or chemical agents which either kill or prevent the growth of microorganisms. Agents which kill cells are called cidal agents; agents which inhibit the growth of cells (without killing them) are referred to as static agents.
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textbookofbacteriology.net/control.html
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To help elucidate why penicillin-G is inactivated by certain bacterial [beta]-lactamase enzymes, whereas clavulanic acid (Clav, which is similar to penicillin-G except at positions 1, 2, and 6) inhibits [beta]-lactamase, the intrinsic chemical reactivities of these two antibiotics were assessed in this work.
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pubs.acs.org/cgi-bin/abstract.cgi/jacsat/2002/124/i40/a...
pubs.acs.org/cgi-bin/abstract.cgi/jacsat/2002/124/i40/abs/ja020788g.html
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