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Genetic disorder - Wikipedia, the free encyclopedia
A genetic disorder is an illness caused by abnormalities in genes or chromosomes. While some diseases, such as cancer, are due in part to a genetic disorders, they can also be caused by environmenta...
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Sex linkage - Wikipedia, the free encyclopedia
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Collectively, these data suggest that down-regulation of GPC3 is a common occurrence in MM and that GPC3, an X-linked recessive overgrowth gene, may encode a negative regulator of mesothelial cell growth. ... The BCL10 gene, located at 1p22, has been implicated in a number of human malignancies,
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Mutations inactivating the STS gene cause X-linked ichthyosis (XLI), ... The clinical presentation and the history of a similar skin condition in the patient's male maternal relatives helped establish the diagnosis of X-linked recessive ichthyosis (XLI). ... hHb6 (human hair basic keratin) gene was used as the internal control.
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3Department of Human Genetics, Memorial Sloan-Kettering Cancer Center, New York, ... Collectively, these data suggest that down-regulation of GPC3 is a common occurrence in MM and that GPC3, an X-linked recessive overgrowth gene, may encode a negative regulator of mesothelial cell growth. Oncogene (2000) 19, 410-416.
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Waisman syndrome, a human X-linked recessive basal ganglia disorder with mental retardation: localization to Xq27 ... Linkage of the gene responsible for an X-linked early onset parkinsonism disorder with mental retardation (McKusick 311510) to DNA probes that detect restriction fragment length polymorphisms is described.
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Gene conversion represents one mechanism by which an X-linked recessive disease may occur in a female. ... Legouis R, Hardelin JP, Levilliers J, et al. The candidate gene for the X-linked Kallmann syndrome encodes a protein related to adhesion molecules. Cell 1991;67:423-435. [CrossRef] [Medline]
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