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Animal cell lines contain a particular sequence known as the "alu gene". There are approximately 900,000 copies of the alu gene distributed throughout the human genome, and multiple copies distributed through the genome of other animal cells, as well.
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www.accessexcellence.org/LC/SS/PS/PCR/PCR_technology.ht...
www.accessexcellence.org/LC/SS/PS/PCR/PCR_technology.html
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The Alu family of short interspersed repeated DNA elements are distributed throughout primate genomes. Over the past 65 million years, the Alu sequence has amplified via an RNA-mediated transposition process to a copy number of about 500,000--comprising an estimated 5% of the human genome.
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www.accessexcellence.org/AE/AEPC/DNA/detection.html
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Some scientists regard Alu as an example of "selfish DNA" – it encodes no protein and appears to exist only for its own replication. If one reduces the definition of life to "the perpetuation and amplification of a DNA sequence through time," then Alu is an extremely successful life form.
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www.geneticorigins.org/pv92/aluframeset.htm
www.geneticorigins.org/pv92/aluframeset.htm
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Alternatively, if we can identify inert Alu elements, sequence-level changes (most usefully, point mutations) between homologous elements should be selectively neutral. A lot of theory has been developed to describe selectively neutral evolution.
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www.stat.berkeley.edu/users/terry/Classes/s260.1998/Wee...
www.stat.berkeley.edu/users/terry/Classes/s260.1998/Week13a/week13a/node6.html
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The unique CK2 " sequence was previously reported within genomic CK2 clone RP5-863C7 (gi:5788437) as an intronic repeat region or Alu sequence (8, 55). The presence of a rarely translated Alu cassette and the remnants of a poly A tail in the cDNA suggests that CK2 " is either a CK2 -derived retroposon (4, 33) or the...
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ajpcell.physiology.org/cgi/content/full/283/2/C472
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T. Dagan, R. Sorek, E. Sharon, G. Ast, and D. Graur; AluGene: a database of Alu elements incorporated within protein-coding genes; Nucleic Acids Res., January 1, 2004; 32(90001): D489 - 492. [Abstract] [Full Text] [PDF];
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ajpcell.physiology.org/cgi/content/abstract/283/2/C472
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We previously identified a T cell-specific enhancer in the last intron of the human CD8 alpha gene that is adjacent to a sequence element that significantly represses enhancer function. This negative regulatory region consists of a half-Alu sequence that has potential to base-pair with a downstream Alu element, which...
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www.aegis.com/aidsline/1995/may/M9550425.html
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Consistent with this idea were the effects of a mutation in SRP RNA that prevented binding of two known SRP proteins to the Alu sequence. CiteULike Complore Connotea Del.icio.us Digg Reddit Technorati Twitter What's this?;
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jcs.biologists.org/cgi/content/abstract/107/4/903
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Alu repeat sequence A member of a family of repeated DNA sequence elements which is particularly abundant in the primates (about 3 × 105 copies in the human genome).
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www.ucl.ac.uk/~ucbhjow/b241/glossary.html
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