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The accumulated acetaldehyde exerts its toxic effects by inhibiting the mitochondria reactions and functions. The alcoholic is a victim of a vicious circle;
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www.elmhurst.edu/~chm/vchembook/642alcoholmet.html
www.elmhurst.edu/~chm/vchembook/642alcoholmet.html
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Acetaldehyde produces unpleasant physiological reactions even at low concentration, so the presence or absence of the gene mutation affecting aldehyde dehydrogenase in turn affects drinking behaviors.
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www.indiana.edu/~rcapub/v17n3/p18.html
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Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholism. Hepatology. ...
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www.ncbi.nlm.nih.gov/pmc/articles/PMC1682953/
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The team found that risk from ingesting acetaldehyde via alcoholic beverages alone may exceed usual safety limits for heavy drinkers. ... Their risk assessment study found that the average exposure to acetaldehyde from alcoholic beverages resulted in a life-time cancer risk of 7.6/10,000, with higher risk scenarios (e...
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www.sciencedaily.com/releases/2009/03/090319102419.htm
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Alcohol, Volume 32, Issue 3, Pages 175-186, April 2004, Authors:Xiaochun Zhang; Shi-Yan Li; Ricardo A Brown; Jun Ren.
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www.journals.elsevierhealth.com/periodicals/alc/article...
www.journals.elsevierhealth.com/periodicals/alc/article/PIIS0741832904000497/abstract
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Cancer ; Enzyme ; Oxidoreductases ; Upper respiratory tract ; Human ; Genetics ; Predisposition ; Malignant tumor ; Saliva ; Genotype ; Aldehyde dehydrogenase (NAD+) ; Consumption ; Alcoholic beverage ; Acetaldehyde ; ... Acetaldehyde ; Alcoholic Beverage ; Aldehyde Dehydrogenase-2 ; Cancer ; Saliva ;
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cat.inist.fr/?aModele=afficheN&cpsidt=20641972
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To explore the role of acetaldehyde in alcoholic cardiomyopathy, we generated transgenic mice with overexpression of the alcohol-metabolizing enzyme alcohol dehydrogenase (ADH) and the acetaldehyde-metabolizing enzyme mitochondrial aldehyde dehydrogenase (ALDH2), driven by myosin heavy chain and chicken beta-actin...
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www.medscape.com/medline/abstract/17590987
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Sera of alcoholic patients were found to contain antibodies to acetaldehyde adducts as determined by immunodiffusion. ... Sera of alcoholic patients were found to contain antibodies to acetaldehyde adducts as determined by immunodiffusion. Differences in antibody levels were determined by hemagglutination with...
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www.medscape.com/medline/abstract/3099350
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THE process for fixation of the intermediate products of alcoholic fermentation by living cells, discovered by Neuberg with the aid of bisulphite, has limitations on account of the toxicity and low power of the salt.
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www.nature.com/nature/journal/v165/n4203/abs/165814a0.h...
www.nature.com/nature/journal/v165/n4203/abs/165814a0.html
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