I typically taper if a patient has taken the medication for more than 3 days. The main reason for a gradual taper is that patients may develop symptoms of steroid (prednisone) withdrawal. These symptoms include: ... Adrenal Crisis...
arthritis.about.com/od/prednisone/f/withdrawaltaper.htm arthritis.about.com/od/prednisone/f/withdrawaltaper.htm
Subject: Suppression of adrenal gland from too high dose of prednisone.; Category: Health; Asked by: mainecoon-ga; ... Hello Maincoon, You didn't say how long you've been taking Prednisone, but generally speaking, if you taper off the dose as directed by your doctor, your adrenal glands should resume their normal function.
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Suppression of the hypothalamic-adrenal axis (HPA) needs to be considered in a patient who has received a glucocorticoid dose comparable to more than 20 mg of prednisone a day for more than 3 weeks. Any patient who has a cushingoid appearance must also be considered at increased risk.
www.medscape.com/viewarticle/533265
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Glucocorticoid - Wikipedia, the free encyclopedia
Glucocorticoids (GC) are a class of steroid hormones that bind to the glucocorticoid receptor (GR), which is present in almost every vertebrate animal cell. The name glucocorticoid ( gluc ose + co...
en.wikipedia.org/wiki/Glucocorticoid
In our small study, we found no difference in relapse rate between asthmatics receiving an 8-day tapering dose of prednisone and those receiving 40 mg/day prednisone upon discharge from the ED. Furthermore, no patients had evidence of adrenal suppression from either dosing regimen.
www.ncbi.nlm.nih.gov/pubmed/9472754
The currently used dosage of dexamethasone caused severe pituitary-adrenal suppression immediately after treatment, but substantial recovery of the endocrine axis was observed 4 weeks after discontinuation of therapy.
jcem.endojournals.org/cgi/content/full/82/8/2429
Although suppression of the hypothalamic-pituitary axis from chronic exogenous steroid use is the most common cause of secondary adrenal insufficiency, the possibility of hypopituitarism due to hypothalamic-pituitary disease must be considered.
emedicine.medscape.com/article/765753-overview