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We found that BLM was essential to correctly relocalize and activate the RMN complex after replication arrest, but not after -rays. On the contrary, an active BLM protein was not crucial in BRCA1 phosphorylation and focus-forming activity, either after replication arrest or -rays.
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We conclude that sister forks can be uncoupled during replication and that, after DSB-induced fork termination, replication is rescued by dormant origin firing or adjacent replicons. We have uncovered a Tel1/ATM- and Mre11-dependent response controlling terminal fork integrity.
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Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans. ... Distinct modes of ATR activation after replication stress and DNA double-strand breaks in ...Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans.
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In this work, the hypothesized involvement of WRN in the restart of DNA synthesis after replication fork collapse has been further investigated, taking into consideration the proper activation of the RAD51-dependent recombinational pathway of DNA synthesis restarting.
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Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest; J. Cell Biol., April 1, 2002; 157(1): 19 - 30. [Abstract] [Full Text] [PDF];
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ANSWER The only way to have albino offspring is the genotype bb. Therefore, the brown parent must have the genotype of Bb. ... ?=b in punnett square shown above. ... 3. Supposing brown eyes in people (B) is dominant to blue (b). Could a marriage between two blue-eyed people produce a brown-eyed child? Could a marriage between...
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The kinetics of replication of vaccine-derived virus strains pMor-1 and Hu2 were similar to that of Ed-wt, with virus being detected by 3 days and peak virus production 7 to 14 days after infection. thy/liv implants infected ... Similar to other virulent viruses (2, 26), pMor-1 and Hu2 replication declined after 14 days.
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