Aldol condensation - Wikipedia, the free encyclopedia
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An Aldol condensation is an organic reaction in which an enolate ion reacts with a carbonyl compound to form a β-hydroxyaldehyde or β-hydroxyketone, followed by dehydration to give a conjugated enon...
en.wikipedia.org/wiki/Aldol_condensation
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Mechanism of the Aldol Addition ... ; Highly Enantioselective Organocatalytic Direct Aldol Reaction in an Aqueous Medium; V. Maya, M. Raj, V. K. Singh, Org. Lett., 2007, 9, 2593-2595.
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www.organic-chemistry.org/namedreactions/aldol-addition...
www.organic-chemistry.org/namedreactions/aldol-addition.shtm
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Mechanism of the Aldol Condensation ... ; Organocatalytic Asymmetric Reaction Cascade to Substituted Cyclohexylamines; J. Zhou, B. List, J. Am. Chem. Soc., 2007, 129, 7498-7499.
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www.organic-chemistry.org/namedreactions/aldol-condensa...
www.organic-chemistry.org/namedreactions/aldol-condensation.shtm
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The overall reaction is an equilibrium, as we would expect since all steps in our mechanism are equilibria. The equilibrium favors aldol product when the carbonyl group is an aldehyde, but does not for ketones.
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chemistry2.csudh.edu/rpendarvis/a-carbaldol.html
chemistry2.csudh.edu/rpendarvis/a-carbaldol.html
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1. Mechanism of Electrophilic α-Substitution ... In the presence of acid or base catalysts the aldol reaction is reversible, and the beta-hydroxy carbonyl products may revert to the initial aldehyde or ketone reactants. In the absence of such catalysts these aldol products are perfectly stable and isolable compounds.
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www.cem.msu.edu/~reusch/VirtualText/aldket2.htm
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The simplest aldol reaction is the condensation of ethanal. This is shown below in 2 different representations (the line diagrams are less cluttered)..... ... MECHANISM OF THE ALDOL CONDENSATION...
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www.mhhe.com/physsci/chemistry/carey5e/Ch18/ch18-3-4.ht...
www.mhhe.com/physsci/chemistry/carey5e/Ch18/ch18-3-4.html
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Macrophomate synthase (MPS) of the phytopathogenic fungus Macrophoma commelinae catalyzes the transformation of 2-pyrone derivatives to the corresponding benzoate analogues. ... The key results are that the Diels−Alder TS model is 17.7 and 12.1 kcal/mol less stable than the Michael and aldol TSs in the stepwise route, r...
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pubs.acs.org/doi/abs/10.1021/ja043905b
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Enantioselective Catalysis of Ketoester-ene Reaction of Silyl Enol Ether to Construct Quaternary Carbons by Chiral Dicationic Palladium(II) Complexes...
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pubs.acs.org/doi/abs/10.1021/ja00068a098
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research.cm.utexas.edu/nbauld/teach/ch610bnotes/ch18/al...
research.cm.utexas.edu/nbauld/teach/ch610bnotes/ch18/aldolmech.htm
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