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We have built a computational model of AZT metabolism in mitochondria in order to better understand these toxicity mechanisms. The model includes the ...
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www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1316...
www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1316272
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1. Bradshaw, PC, Li J and Samuels DC (2005) A computational model of mitochondrial AZT metabolism, Biochemical Journal, vol. 1, no. 392: 363-373; Samuels DC (2006) Mitochondrial AZT metabolism, IUBMB Life, vol. 58, no.7: ... Home Public Relations Press Releases Computational model simulates AZT metabolism in mitochondria...
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www.vbi.vt.edu/public_relations/press_releases/azt
www.vbi.vt.edu/public_relations/press_releases/azt
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To test the effect of a concurrently administered drug on the elimination of AZT in the model, some rats with bile duct cannulas were pretreated with ...
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jpet.aspetjournals.org/content/259/3/1261.abstract
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Hemopoietic Recovery from AZT Toxicity with Recombinant Hemoglobin in a Murine Model of AIDS; S. Moqattasha, J.D. Luttonb, M.F. Abu-Hijleha, N.G. Abrahama; aDepartment of Human and Clinical Anatomy, Sultan Qaboos University, Muscat, Sultanate of Oman;
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content.karger.com/ProdukteDB/produkte.asp?Doi=204217
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Conclusion: A relatively simple PK model can predict disposition of AZT in pregnancy. Applications include minimal sampling strategy to capture PK/PD targets and modeling other drug products used during pregnancy...
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www.nature.com/clpt/journal/v77/n2/abs/clpt2005163a.htm...
www.nature.com/clpt/journal/v77/n2/abs/clpt2005163a.html
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Very often, the efficient study of a disease involves the development of an animal model of that disease. In the case of AIDS, there are several animal models, but no single model is completely satisfactory. One model is the LP-BM5 mouse. ... AZT demonstrates anti-HIV-1 activity in persistently infected cell lines:
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www.faqs.org/abstracts/Health/Zidovudine-AZT-reduces-vi...
www.faqs.org/abstracts/Health/Zidovudine-AZT-reduces-virus-titer-retards-immune-dysfunction-and-prolongs-survival-in-the-LP-BM5-mu.html
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However, after oral AZT administration, the observed terminal half-lives reflect drug absorption rather than drug elimination (i.e., a flip-flop kinetic model is operable). There is some evidence to suggest that the disappearance of AZT from the blood of orally dosed AIDS patients may also be controlled by drug absorption.
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www.medscape.com/medline/abstract/2277865
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For this purpose, they have been developing a detailed computational model that allows scientists to simulate the biochemical reactions that take place when AZT is metabolized in cells, including their mitochondria, ... Biology Articles » Bioinformatics » Computational model simulates AZT metabolism in mitochondria...
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www.biology-online.org/articles/computational_model_sim...
www.biology-online.org/articles/computational_model_simulates_azt.html
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Biology News Articles & Current Events, Updated Daily ... For this purpose, they have been developing a detailed computational model that allows scientists to simulate the biochemical reactions that take place when AZT is metabolized in cells, including their mitochondria, under different metabolic conditions.
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www.biologynews.net/archives/2006/07/24/computational_m...
www.biologynews.net/archives/2006/07/24/computational_model_simulates_azt_metabolism_in_mitochondria.html
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