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It is urgently necessary to review the toxicity of AZT in light of recent marketing developments. ... The old rationale for prescribing AZT was that people with AIDS (PWAs) were suffering from a disease that was invariably fatal, that such persons had only a few months ... The Chernov Review of AZT's Pharmacology & Toxicity...
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www.virusmyth.net/aids/data/jlcancer.htm
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"WARNING: RETROVIR (ZIDOVUDINE) [AZT] MAY BE ASSOCIATED WITH HEMATOLOGIC TOXICITY INCLUDING GRANULOCYTOPENIA AND SEVERE ANEMIA PARTICULARLY IN PATIENTS WITH ADVANCED HIV DISEASE ( SEE WARNINGS).
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www.oldamericancentury.org/azt.htm
www.oldamericancentury.org/azt.htm
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The hematologic toxicity of AZT was more severe than that of ddC. Generally, toxic effects of either chemical were greater in mice than in rats and more pronounced in female than in male animals. After 30 days without dosing, hematologic effects either resolved or dramatically improved.
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toxsci.oxfordjournals.org/cgi/content/abstract/17/1/159
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The hematologic toxicity of AZT was more severe than that of ddC. Generally, toxic effects of ... sensitive than rats to the toxic effects of AZT. ...
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toxsci.oxfordjournals.org/cgi/reprint/17/1/159.pdf
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Furthermore, since some of the clinical and laboratory manifestations of AZT toxicity mimic AIDS, it is impossible to differentiate between AZT toxicity and AIDS. *---By Eleni Papadopulos et al.
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www.whale.to/a/azt_q.html
www.whale.to/a/azt_q.html
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Original Article from The New England Journal of Medicine -- The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial ... Concurrent use of acetaminophen was also associated with a higher frequency of hematologic toxicity. Although a subset...
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content.nejm.org/cgi/content/abstract/317/4/192
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The toxicities of ... The toxicities of AZT and ddI have been described in past issues of TreatmentUpdate. The toxic effects of AZT on the immune system are reported in TreatmentUpdate 24, 26 and 41. Side effects of ddI appear in TreatmentUpdate 25 and 27.
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www.aegis.com/pubs/catie/1993/CATI4311.html
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This study has the purpose to prepare anti CD4 MAB, CD14 and CD38 mab- labelled liposomes containing AZT to achieve a selective cell-targeting avoiding toxicity on non target cells.
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www.aegis.com/conferences/iac/1992/PuB7441.html
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Concurrent use of acetaminophen was also associated with a higher frequency of hematologic toxicity. Although a subset of patients tolerated AZT for an extended period with few toxic effects, the drug should be administered with caution because of its toxicity and the limited experience with it to date.
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www.medscape.com/medline/abstract/3299090
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