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Currently, three classes of bactericidal antibiotics are used to target different bacterial functions: inhibiting DNA replication, blocking protein-building, or halting construction of cell walls. Research from the laboratory of James Collins found a common process that was triggered by all three types of antibiotics.
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www.genengnews.com/news/bnitem.aspx?name=22714349
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C. Categories of Antibiotics; Antibiotics are categorized as bactericidal if they kill the susceptible bacteria or bacteriostatic if they reversibly inhibit the growth of bacteria. In general the use of bactericidal antibiotics is preferred but many factors may dictate the use of a bacteriostatic antibiotic.
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pathmicro.med.sc.edu/mayer/antibiot.htm
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Treatment failures and relapses are frequent, especially following brief antibiotic courses, and this contrasts with the in-vitro susceptibility of B. henselae to most antibiotics. ... We carried out a bactericidal assay in this model and in axenic broth. In both models, only aminoglycosides were bactericidal.
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www.medscape.com/medline/abstract/8537257
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We hypothesized that treatment of experimental sepsis with bactericidal antibiotics, known to enhance microbial toxin release, would alter tumor necrosis factor-alpha production and the hemodynamic response to the syndrome. ... The Medscape Journal ... Allergy & Clinical Immunology...
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www.medscape.com/medline/abstract/8013063
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An inherent limitation of this design is that if two different antibiotics, one bactericidal and the other bacteriostatic, are used, it will be impossible to determine whether differences in outcome are because of differences in antibacterial activity or due to other differences that unavoidably will be present...
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www.nfid.org/pdf/id_archive/antibiotictherapy.pdf
www.nfid.org/pdf/id_archive/antibiotictherapy.pdf
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Here we show that the three major classes of bactericidal antibiotics, regardless of drug-target interaction, stimulate the production of highly deleterious hydroxyl radicals in Gram-negative and Gram-positive bacteria, which ultimately contribute to cell death.
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www.cell.com/abstract/S0092-8674(07)00899-9
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The fluoroquinolones are bactericidal antibiotics that act by specifically targeting DNA gyrase.10 In contrast to aminoglycosides and beta-lactams, some fluoroquinolones are active against dormant and replicating bacteria.5 Fluoroquinolones exhibit a postantibiotic effect following bacterial exposure to...
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www.aafp.org/afp/20000501/2741.html
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A recent publication suggests that many antibiotics exert their bactericidal effects via the production of hydroxyl radicals, regardless of their molecular targets. This proposal represents an abrupt departure from conventional models, and it will attract further experimental tests. ... † Department of Genetics,
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pubs.acs.org/doi/abs/10.1021/cb700232k
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Select item below ... Question and Answer Archive ... Can you tell me about bacteriostatic and bacteriocidal antibiotics?
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www-saps.plantsci.cam.ac.uk/records/rec158.htm
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