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Multiplicity of infection - Wikipedia, the free encyclopedia
The multiplicity of infection or MOI is the ratio of infectious agents (e.g. phage or virus) to infection targets (e.g. cell). For example, when referring to a group of cells inoculated with infec...
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Multiplicity of infection (MOI) is a parameter that has been commonly used to predict viral infectivity in a population of target cells. With wild type viruses, an "infectious unit" refers to the smallest amount of virus capable of producing an infection in a susceptible cell.
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however, viral gene expression during an attenuated low-multiplicity infection by CR208 was more extensive than was previously observed for RC303 Acc, indicating that IE1 p72 function may have a strong impact at multiple stages of the virus life cycle.
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These findings are encouraging since in the majority of infections a vaccine-mediated response may have to protect against only a low-multiplicity infection event that is associated with low viral diversity in the initial days and weeks of infection.
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The Multiplicity of Infection of a Plant Virus Varies during Colonization of Its Eukaryotic Host; J. Virol., August 1, 2009; 83(15): 7487 - 7494. [Abstract] [Full Text] [PDF];
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