It is and effect on a cell negatively. it can be multinuclearity, membrane blebbing, vacuolization, giantism and cellular distortion
http://wiki.answers.com/Q/What_is_cell_aberration
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Another 346 patients (22.1%) showed single cell aberrations; the significance of these is unclear at the moment. Constitutional chromosome aberrations were detected in 69 patients. ... If a structural or numerical aberration was found in only one cell, it was disregarded as a single cell aberration.
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humrep.oxfordjournals.org/cgi/content/full/14/9/2257
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One hundred forty-six tumors did not show clonal abnormalities, but single-cell aberrations other than monosomies occurred in 79 of these tumors. ...
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linkinghub.elsevier.com/retrieve/pii/0165460894001647
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MTS1/p16, encoding a negative cell cycle regulator, is located near D9S171 within chromosomal region 9p21-23. Inactivation of this gene has been found in a variety of human cancers caused by different mechanisms, including mutation, homozygous deletion of MTS1/p16 loci or hypermethylation of 5'CpG island25, 26, 27.
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www.nature.com/cr/journal/v10/n4/full/7290058a.html
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B cell, chromosome aberration, comparative genomic hybridization, cutaneous lymphoma, fluorescence in situ hybridization ... In contrast, in systemic B cell lymphomas typical aberration patterns have been described for the different subtypes and genetic analysis has become an important tool for their differential diagnosis.
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www.nature.com/jid/journal/v122/n6/full/5602372a.html
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PURPOSE: To investigate further the relationship between high linear energy transfer (LET) induced cell cycle arrests and the yield of chromosome aberrations observable in normal human fibroblasts at the first post-irradiation mitosis. ... Furthermore, a mathematical approach was used to analyse the entire cell population.
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www.medscape.com/medline/abstract/17613123
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Oncogenic transformation leads to cell cycle aberration and apoptosis dysregulation. ... Oncogenic transformation leads to cell cycle aberration and apoptosis dysregulation. Targeting cell cycle and apoptosis pathways has emerged as an attractive approach for the treatment of cancer.
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www.medscape.com/medline/abstract/15530779
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Cell traversed by a charged particle has certain probability to receive lethal damage leading to direct death. ... From these assumptions, the frequency of chromosome aberration in surviving cells can be described by Y = αSD + βS^2 D^2 with the empirical relation Y = αD + βD^2 in the low LET region, where S = e^<-cL> ,
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ci.nii.ac.jp/naid/110002328823/
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In the present study chromosomal aberration analysis and the alkaline single cell gel electrophoresis (Comet) assay were used to evaluate the extent of DNA damage and DNA repair in peripheral blood lymphocytes of subjects employed in pesticide production.
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mutage.oxfordjournals.org/cgi/content/abstract/16/4/359
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