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Action potential - Wikipedia, the free encyclopedia
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Depolarization - Wikipedia, the free encyclopedia
In biology, depolarization is a change in a cell's membrane potential, making it more positive, or less negative. In neurons and some other cells, a large enough depolarization may result in an acti...
en.wikipedia.org/wiki/Depolarization |
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The sudden complete depolarization of the membrane opens up more of the voltage-gated sodium channels in adjacent portions of the membrane. In this way, a wave of depolarization sweeps along the cell. This is the action potential (In neurons, the action potential is also called the nerve impulse.)
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Many cells in the body have the ability to undergo a transient depolarization and repolarization that is either triggered by external mechanisms (e.g., motor nerve stimulation of skeletal muscle or cell-to-cell depolarization in the heart) or by intracellular, spontaneous mechanisms (e.g., cardiac pacemaker cells).
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Cell depolarization in hemorrhagic shock has been attributed to hypoperfusion, but the mechanism remains unclear. Suspensions of single cell lines loaded ...
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The popularity of DA-cell depolarization block theory stands on the fact that it provides a potential mechanism to account for the delayed antipsychotic ...
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1Programme in Cell Biology, The Hospital for Sick Children; and 2Department of Physiology, University of Toronto, Toronto, Ontario, Canada ... Muscle contraction is elicited by membrane depolarization followed by a rise in cytosolic Ca2+ and actomyosin activation, drawing on ATP stores. It is unknown whether one or more...
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