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A molecule can have multiple chiral centers without being chiral overall if there is a symmetry between the two (or more)
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Encyclopedia: Stereocenter
A stereocenter, or stereogenic centre, is any atom in a molecule bearing groups such that an interchanging of any two groups leads to a stereoisomer . In organic chemistry this usually refers to a ca...
en.wikipedia.org/wiki/Stereocenter |
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Molecules can also be chiral if they contain one or more chiral centers. For the purposes of introductory organic chemistry, a chiral center can be defined as an sp3 hydridized carbon which is bonded to four different groups.
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Chiral Center definition, as used in chemistry, chemical engineering, and physics.
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Please read! Important notes about this presentation. This presentation is designed to be used as an adjunct to traditional lectures not as a replacement. I suspect that it will be most useful as a review of the material. Stereoisomers in Molecules with One Chiral Center...
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When more than one chiral center is present in a molecular structure, care must be taken to analyze their relationship before concluding that a specific molecular configuration is chiral or achiral. This aspect of stereoisomerism will be treated later.
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Here is a systematic way to go about writing all of the stereoisomers for a molecule with several chiral centers. Start by drawing a zig-zag backbone, with one corner for each chiral center:
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The characteristic structural features of R-(+)-pulegone are the presence of an -isopropylidene ketone unit and a chiral center at C-5. Both these structural features appear to be necessary for the compound to elicit maximum toxicity (Gordon et al., 1982 ). In fact, the C-5 methyl group should have a proper orientation...
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A molecule requires the presence of a chirality center - this is what we will be exploring here. Terms such as an asymmetric, stereogenic or chiral center have been used in the past.
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PDR-Chiral Inc. - makers of the Advanced Laser Polarimeter, has created this web site to provide analytical chemists with a basic understanding of detection used in chiral analysis.
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