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Eukaryotic genetic replication involves both DNA synthesis and chromatin assembly. Chromosomal DNA synthesis is similar to prokaryotic DNA replication in that each of the ... the replicating chromatin may be pulled through these sites. A number of DNA polymerases exist in the nucleus.
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www.cliffsnotes.com/WileyCDA/CliffsReviewTopic/Chromati...
www.cliffsnotes.com/WileyCDA/CliffsReviewTopic/Chromatin-Replication.topicArticleId-24594,articleId-24586.html
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We also show that the whole region, including the stretch of condensed chromatin, replicates early in S phase in these cells. Therefore, different early-firing origins within the same locus may have opposite patterns of epigenetic modifications.
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www.epidna.com/showabstract.php?pmid=12724412
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The functional significance of this program is not understood, but, in general, transcriptionally active chromatin replicates early in S phase, ...
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www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2199...
www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2199609
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Two Parents contribute Genes:
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www.biology.lsu.edu/introbio/summer/Summer2003/1201/Cha...
www.biology.lsu.edu/introbio/summer/Summer2003/1201/Chap%2013%20review.htm
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Histone deposition occurs primarily as DNA replicates to complete chromatin doubling (1~. During S phase of the cell cycle, new histones are produced in abundance for immediate replication-coupled deposition.
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books.nap.edu/openbook.php?record_id=10620&page=101
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As chromatin replicates, Mcm(2-7) are removed, thus preventing the origin from firing again. Here we report the purification of the RLF-B component of the licensing system and show that it corresponds to Cdt1. RLF-B/Cdt1 was inhibited by geminin, a protein that is degraded during late mitosis.
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lib.bioinfo.pl/auid:1415998
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Minimally licensed chromatin replicates poorly in the presence of aphidicolin and caffeine; When demembranated sperm nuclei are incubated in X. laevis egg extracts, an average of 10–20 Mcm2–7 complexes are loaded onto each replication origin before entry into S phase (Mahbubani et al., 1997;
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jcb.rupress.org/cgi/content/full/173/5/673
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In general, transcriptionally active chromatin replicates early in S phase whereas transcriptionally inactive chromatin replicates later. Here we provide evidence for significant deviation from this dogma in mouse NIH3T3 cells.
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www.ncbi.nlm.nih.gov/pubmed/16231189
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Chromatin present in the dense nucleolar component and fibrillar centres, irrespective of being active or inactive, replicates in the early S — phase, ...
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linkinghub.elsevier.com/retrieve/pii/030916519090034V
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