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Cystinuria is a genetic defect in the kidney tubules. Normal kidneys filter the amino acid cystine and do not allow it to go into the urine. In dogs with cystinuria, this filtering action fails, and cystine passes into the urine, where it can form crystals and/or stones (uroliths).
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www.caninecystinuria.com/FAQ.html
www.caninecystinuria.com/FAQ.html
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Information and education on canine cystinuria. ... One study suggests that as few as 1 in 6 dogs with cystinuria form stones. However, our knowledge of this condition is not complete enough to state the risk with certainty.
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www.caninecystinuria.com/
www.caninecystinuria.com/
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Not all dogs with cystinuria will actually develop kidney stones or deposits that are problematic for the dog. If stones do form and are blocking and restricting the movement of urine out of the body the results can be fatal.
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www.terrificpets.com/articles/102108865.asp
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Cystinuria and Kidney Stones In Dogs ... Cystinuria is a congenital genetic defect, which means that puppies are born with the condition but it may not become developed until the puppies mature. That is not to say the puppies may not have trouble with kidney stones even at a young age, it will vary greatly from dog to dog.
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www.terrificpets.com/articles/dogs/medical/digestive%2D...
www.terrificpets.com/articles/dogs/medical/digestive%2Dproblems/Cystinuria/
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Although cystinuria affects many dog and cat breeds, the most severe form seems to affect Newfoundland dogs. Cystinuria is inherited as an autosomal recessive trait in the Newfoundland dog. In other words, affected Newfoundland dogs have two mutant genes, one inherited from each parent.
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research.vet.upenn.edu/LinkClick.aspx?fileticket=ekWr0O...
research.vet.upenn.edu/LinkClick.aspx?fileticket=ekWr0O4Rakc%3D&tabid=545&mid=960
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Treating a dog with Cystinuria for other types of stones can be deadly! Supplementing with acidifiers such as vitamin C can cause stones to form in ...
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mastiff.org/health/cystine.htm
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This diet has been formulated by Jeni Boniface info@pets4life.com and Trina Nowak trina@nowak.on.ca, to assist dogs diagnosed with cystinuria. We are not veterinarians; we cannot and do not presume to diagnose your dog.
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devinefarm.net/health/cysintro.htm
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Cystinuria in Newfoundland dogs is a metabolic disease associated with a nonsense mutation in the exon 2 of the Slc3a1 gene. Similar to type I human cystinuria, heterozygote carriers are not affected by the disease and do not reveal differences in urinary concentration of dibasic amino acids when compared with normal dogs.
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www.jvdi.org/cgi/content/abstract/18/1/102
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Cystinuria in dogs: comparison of the cystinuric component of the Fanconi syndrome in basenji dogs to isolated cystinuria. ... Cystinuria in dogs: comparison of the cystinuric component of the Fanconi syndrome in base...Cystinuria in dogs: comparison of the cystinuric component of the Fanconi syndrome in basenji dogs...
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www.ncbi.nlm.nih.gov/pubmed/2909832
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