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Cystinuria in Newfoundland Dogs; By Sharon Gwaltney DVM PhD; ... Dogs with cystinuria do not properly reabsorb cystine (and a few other amino acids) in the kidney tubules, causing the urine to contain abnormally high levels of cystine.
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www.vetprof.com/clientinfo/newf-cystinuria.html
www.vetprof.com/clientinfo/newf-cystinuria.html
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Cystinuria is a genetic defect in the kidney tubules. Normal kidneys filter the amino acid cystine and do not allow it to go into the urine. In dogs with cystinuria, this filtering action fails, ... Some breeds, such as Scottish Deerhounds, have yet to identify even one female who has it, whereas in the Newfoundland,
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www.caninecystinuria.com/FAQ.html
www.caninecystinuria.com/FAQ.html
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Although cystinuria affects many dog and cat breeds, the most severe form seems to affect Newfoundland dogs. Cystinuria is inherited as an autosomal ...
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research.vet.upenn.edu/LinkClick.aspx?fileticket=ekWr0O...
research.vet.upenn.edu/LinkClick.aspx?fileticket=ekWr0O4Rakc%3D&tabid=545&mid=960
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Although cystinuria affects many dog breeds, the most severe form affects Newfoundland dogs. Cystinuric dogs often show signs of a recurrent urinary tract disorder. Clinical signs may start at almost any age. Affected dogs may have problems with urination.
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www.bearadisenewfoundlands.com/healthissues.html
www.bearadisenewfoundlands.com/healthissues.html
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Cystinuria in Newfoundland dogs is a metabolic disease associated with a nonsense mutation in the exon 2 of the Slc3a1 gene. ...
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jvdi.org/cgi/content/abstract/18/1/102
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Cystinuria in Newfoundland dogs is a metabolic disease associated with a nonsense mutation in the exon 2 of the Slc3a1 gene. ... However, it should be noted that the results herein are limited to the genetic screening of the only known cystinuria-related mutation in Newfoundland dogs.
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jvdi.org/cgi/reprint/18/1/102.pdf
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A mutation-specific test was developed for the diagnosis and control of cystinuria in Newfoundland dogs. In cystinuric dogs of six other breeds, ...
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cat.inist.fr/?aModele=afficheN&cpsidt=813636
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AKC Newfoundland Dogs ... Additionally, we test for cystinuria so that we are certain that our puppies will not be affected. Another significant problem in the breed is an inherited heart murmur referred to as a stenosis. This is an untreatable heart condition that can significantly shorten the life of a dog.
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www.newfoundlanddog.com/
www.newfoundlanddog.com/
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