Small population size - Wikipedia, the free encyclopedia
Small populations behave differently from larger populations. Often this has various harmful consequences for the survival of that population. The influence of stochastic variation in demographic (re...
en.wikipedia.org/wiki/Small_population_size
Mutation-selection balance - Wikipedia, the free encyclopedia
The mutation-selection balance is a classic result in population genetics first derived in the 1920s by John Burdon Sanderson Haldane and R.A. Fisher. A genetic variant that is deleterious will not ...
en.wikipedia.org/wiki/Mutation-selection_balance
When the population is large, this is generally not a problem—the population may carry many recessive deleterious alleles, but they are rarely expressed. However, when the population becomes small, close relatives end up mating with one another, and those relatives likely carry the same recessive deleterious alleles.
evolution.berkeley.edu/evosite/relevance/IIIA1Inbreedin... evolution.berkeley.edu/evosite/relevance/IIIA1Inbreeding.shtml
The effect of deleterious alleles on adaptation in asexual populations. ... We show that when selection against deleterious alleles is weak, beneficial alleles that confer a selective advantage that is small relative to U have greatly reduced probabilities of fixation. We discuss the consequences of this effect for...
www.ncbi.nlm.nih.gov/pubmed/12242249
Deleterious alleles - reduce the likelihood of an individual’s survival ; - act by : - reducing probability of an individual’s survival ; - less able to obtain food ; - less able to digest food ;
www.meredith.edu/biology/reid/bio101/notes10.htm
We show that when selection against deleterious alleles is weak, beneficial alleles that confer a selective advantage that is small relative to U have greatly reduced probabilities of fixation. We discuss the consequences of this effect for the distribution of effects of alleles fixed during adaptation.
www.genetics.org/cgi/content/abstract/162/1/395
This mating type-ratio bias is caused by the presence of deleterious alleles at haploid phase, so called “haplo-lethals”, which are linked to the mating type locus. These haplo-lethals may persist in a heterozygous state if there is premature conjugation among the products of meiosis, i.e. intratetrad selfing.
www.ese.u-psud.fr/genetique/alleles-deleteres/index-en.... www.ese.u-psud.fr/genetique/alleles-deleteres/index-en.html
BioInfoBank Library :: Fixation of deleterious alleles, evolution and human aging. Differentiation-specific effects of LHON mutations introduced into neuronal NT2 cells. A neutral theory predicts multigenic aging and increased concentrations of deleterious mutations on the mitochondrial and Y chromosomes. ... Mech Ageing Dev.
lib.bioinfo.pl/pmid:12044933
The cause of mating-type bias was identified as deleterious recessive alleles linked to mating type. Maintenance of the deleterious alleles was promoted by early conjugation among products of single meioses, such that the duration of the free-living haploid stage is minimized.
www.nature.com/hdy/journal/v85/n3/full/6887480a.html
This inviability is thought to result from unmasked deleterious alleles on the clonally transmitted R genomes. Most simply it reflects homozygosity for recessive deleterious alleles at particular loci;
www.ncbi.nlm.nih.gov/pubmed/12093017