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The different eye color phenotypes among Drosophila result from alterations in biochemistry. George W. Beadle and Edward L. Tatum demonstrated in the 1940's that genes regulate biochemical processes by controlling the production of enzymes.
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www.accessexcellence.org/AE/AEPC/WWC/1994/characterizin...
www.accessexcellence.org/AE/AEPC/WWC/1994/characterizing_drosophila.php
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1) To familiarize you with an important research organism, the fruit fly, Drosophila melanogaster. ... In your lab notebook, describe their morphology paying particular attention to eye color, body color, and wing shape. You should begin with a wild type fly so that you will have some basis for comparison. You may want to...
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math.hws.edu/mathbeans/ryan/Genetics1.html
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The biochemical pathway shown below is an updated figure similar to one taken from an undergraduate lab manual where students identify the pigments by thin layer chromatography [Thin Layer Chromatography of Eye Pigments of Drosophila melanogaster]. Four other eye color mutants, Punch, purple, sepia and clot disrupt...
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sandwalk.blogspot.com/2007/09/eye-color-in-fruit-flies....
sandwalk.blogspot.com/2007/09/eye-color-in-fruit-flies.html
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Published on 22 May 2006 as manuscript BJ20060424 Identification and characteristics of the structural gene for the Drosophila eye color mutant sepia, encoding PDA synthase, a member of the Omega class glutathione S-transferases Jaekwang Kim1, Hyunsuk Suh1, Songhee Kim, Kiyoung Kim, Chiyoung Ahn2 and Jeongbin Yim3 School...
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www.biochemj.org/bj/imps_x/pdf/BJ20060424.pdf
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I investigated the Drosophila eye using electrophysiology, one of the most powerful techniques of neuroscience. Taking advantage of Drosophila's eye color mutants, I determined the absorbance of eye color pigments and their effects on visual sensitivity.
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starklab.slu.edu/eyecolor1.htm
starklab.slu.edu/eyecolor1.htm
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Also, this paper has been cited which helped me to find some interesting new developments, e.g.: V Lloyd et al., Not just pretty eyes: Drosophila eye color mutations and lysosomal delivery, Trends in Cell Biology 8, 257-259, 1998. (in which it is stated that pigment granules are specialized lysosomes);
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starklab.slu.edu/EyeColor/EyeColorLecture.htm
starklab.slu.edu/EyeColor/EyeColorLecture.htm
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LXVI, May-June, 1932 COMPLEMENTARY FACTORS FOR EYE COLOR IN DROSOPHILA Bridges (`19) and Bridges and Morgan (`23) have described the effects of a large number of combinations of factors on eye color in Drosophila.
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www.esp.org/foundations/genetics/classical/wright01.pdf
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Thomas Hunt Morgan (1866-1945), was the first to observe the white eye mutation in Drosophila in 1910. The wild type normal eye color is red. What caused this mutation? And how was this change transmitted?
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www.yale.edu/ynhti/curriculum/units/1996/5/96.05.01.x.h...
www.yale.edu/ynhti/curriculum/units/1996/5/96.05.01.x.html
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You'll see enlarged illustrations of fruit flies, Drosophila melanogaster. (In our real exhibit you'd be looking at the actual flies crawling around, looking for food or grooming ... These are normal fruit flies, or "wildtypes." Notice that their eye color is bright red. Compare them with the other fruit flies here.
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www.exploratorium.edu/exhibits/mutant_flies/mutant_flie...
www.exploratorium.edu/exhibits/mutant_flies/mutant_flies.html
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