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Antiemetic - Wikipedia, the free encyclopedia
An antiemetic is a drug that is effective against vomiting and nausea. Antiemetics are typically used to treat motion sickness and the side effects of opioid analgesics, general anaesthetics and che...
en.wikipedia.org/wiki/Antiemetic |
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Antiemetic drugs are used to control excessive vomiting once an etiologic diagnosis has been made, to prevent motion sickness and psychogenic vomiting, and to control emesis from radiation and chemotherapy ... These are usually administered in emergency situations after ingestion of a toxin (Table: Emetic Drugs).
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In the study of potential anti-emetic drugs, the lab animals appropriate for use are ferrets, dogs, cats and monkeys, since these species have a vomit reflex comparable to humans. Rodents and rabbits are not used, since they do not have such a vomit mechanism.
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It is notable that other classes of anti-emetic drug such as the 5-hydroxytryptamine3 (5-HT3) and tachykinin NK1 receptor antagonists have not been ...
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[5] Wang SC. Emetic and antiemetic drugs. In Root WS, Hofmann FG (eds) Physiological Pharmacology II, pp 255-328, Academic Press, New York (1965). ... [13] Davies PR, Warwick P, O'Connor M. Antiemetic efficacy of ondansetron with patient controlled analgesia. Anaesthesia 51, 880-882 (1996).
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overall exposure rate to any anti-emetic drug is lower than the sum of the exposure rates of ..... of possibly contraindicated anti-emetic drugs prescribed ...
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The sites of action of sensory stimuli causing vomiting are linked in a figure with the probable sites of action of anti-emetic drugs. Three main groups of anti-emetic drugs are discussed, general sedatives and tranquillizers, hyoscine and atropine, and certain antihistamines.
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