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Many enzymes are subject to allosteric control, ... Phosphofructokinase in Escherichia coli is such an enzyme, being inhibited by phosphoenolpyruvate (PEP) and activated by ADP and GDP1. How do individual interactions with effectors affect the balance between activation and inhibition, especially when both ligands share...
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www.nature.com/nature/journal/v326/n6115/abs/326811a0.h...
www.nature.com/nature/journal/v326/n6115/abs/326811a0.html
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They possess agonist recognition sites and allosteric sites where modulators regulate ion channel function. Using strychnine-sensitive glycine receptors, we identified a scaffold of hydrophobic residues enabling allosteric communication between glycine-agonist binding loops A and D, and the Zn2+-inhibition site.
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www.nature.com/nsmb/journal/v15/n10/full/nsmb.1492.html
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Mapping a molecular link between allosteric inhibition and activation of the glycine receptor. ... Mapping a molecular link between allosteric inhibition and activation of the glycine recep...Mapping a molecular link between allosteric inhibition and activation of the glycine receptor.
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www.ncbi.nlm.nih.gov/pubmed/18806798
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... a rational for the potency of the inhibitor and explain GPa allosteric inhibition of activity upon ... Crystallographic binding studies on the allosteric inhibitor ... of the nucleotide activation switch in glycogen phosphorylase a. ...
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www.ncbi.nlm.nih.gov/pmc/articles/PMC2144149/
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Loss of Allosteric Inhibition Conferred by Mutations ... ponsible for the observed valine activation, probably via changed properties on the proposed regulatory-cata- ... aim of the present study was: (1) to explain the loss of AHAS ...
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www.springerlink.com/index/W752P12X30173827.pdf
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24. Distinguish between allosteric activation and cooperativity ; 25. Explain how metabolic pathways are regulated ... a. Allosteric regulation b. Feedback inhibition c. cooperativity...
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www.jdenuno.com/APBiology/AP~Metabolism.htm
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Mechanism for allosteric inhibition of an ATP-sensitive ribozyme; Introduction; Materials And Methods; RNA and DNA molecules; Ribozyme assays; Binding assays; Molecular modeling; Results And Discussion; ... Therefore, loss of ATP binding potential alone cannot explain the observed loss of allosteric control wit...
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nar.oxfordjournals.org/cgi/content/full/26/18/4214
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Different modification mechanisms are analysed: mixed inhibition, allosteric inhibition and activation of the reversible Monod-Wyman-Changeux and reversible Hill models.
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lib.bioinfo.pl/pmid:11594728/pmid/sim
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Briefly explain the allosteric regulation of ATCase, including its quaternary structure, its role in metabolism, and how its activity is regulated by allosteric inhibition and activation. Include the physiological rationale for the inhibition and activation.
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www.biochem.arizona.edu/classes/bioc460/summer/460web/l...
www.biochem.arizona.edu/classes/bioc460/summer/460web/lecture/EnzReg1_09.pdf
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