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Alternate Name(s): Type II hyperlipoproteinemia; Hypercholesterolemic xanthomatosis; Low density lipoprotein receptor mutation ...... A dominantly inherited genetic condition that results in markedly elevated LDL (low-density lipoprotein) cholesterol levels beginning at birth, and resulting in heart attacks at an early age.
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www.nlm.nih.gov/medlineplus/ency/article/000392.htm#Def...
www.nlm.nih.gov/medlineplus/ency/article/000392.htm#Definition
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announced results from its ongoing Phase 2 clinical trial of ISIS 301012 in patients with homozygous familial hypercholesterolemia (HoFH), presented today at the of Cardiology Annual Scientific Session (ACC) in New Orleans.
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www.drugs.com/clinical_trials/isis-pharmaceuticals-repo...
www.drugs.com/clinical_trials/isis-pharmaceuticals-reports-positive-phase-2-data-isis-301012-familial-hypercholesterolemia-393.html
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announced updated results from its ongoing Phase 2 clinical trial of ISIS 301012 in patients with homozygous familial hypercholesterolemia (HoFH), initial results of which were presented in March at the of Cardiology Annual Scientific Session (ACC) in New Orleans.
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www.drugs.com/clinical_trials/isis-pharmaceuticals-upda...
www.drugs.com/clinical_trials/isis-pharmaceuticals-updates-positive-phase-2-data-isis-301012-familial-hypercholesterolemia-876.html
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Overview: Familial hypercholesterolemia (FH) is an autosomal dominant disorder that causes severe elevations in total cholesterol and low-density lipoprotein cholesterol (LDLc). Although moderate hypercholesterolemia is a common finding in industrialized countries, heterozygous FH occurs in approximately 1 ...
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emedicine.medscape.com/article/121298-overview
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Familial hypercholesterolemia - Overview, Familial hypercholesterolemia is a condition passed down through families in which a person has high levels of "bad" cholesterol (low density lipoprotein, or LDL) beginning at birth. ... Familial hypercholesterolemia is caused by a gene defect on chromosome 19. The defect makes the...
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www.umm.edu/ency/article/000392.htm
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How is familial hypercholesterolemia diagnosed? ... NHGRI Clinical Research on Familial Hypercholesterolemia ... Men who have familial hypercholesterolemia have heart attacks in their 40's to 50's, and 85 percent of men with the disorder have a heart attack by age 60. Women who have familial hypercholesterolemia also have...
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Familial Hypercholesterolemia (FH) is an inherited disorder that causes very high cholesterol levels and greatly increases the chance of having a heart attack early in life. Heart attacks usually occur in men when they are 40-55 years old and in women when they are 50-65 years old.
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www.medped.org/MEDPED-What-is-FH.html
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