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In clinical settings genetic heterogeneity refers to the presence of a variety of genetic defects which cause the same disease, often due to mutations at different loci on the same gene, a finding common to many human diseases including ALZHEIMER DISEASE;
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Genetic heterogeneity - Wikipedia, the free encyclopedia
The phenomenon that a single disorder may be caused by different allele or non-allele mutation. For example, Retinitis Pigmentosa has autosomal dominant, autosomal recessive, and X-linked origins.
en.wikipedia.org/wiki/Genetic_heterogeneity |
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Studies of LQTS have demonstrated genetic heterogeneity, that is, the disease phenotype can arise from mutations in any one of multiple (probably at least seven) genes (2). Important direct consequences of these genetic studies have included:
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Amniocentesis A procedure used in antenatal diagnosis of genetic abnormality in which a sample of the amniotic fluid surrounding the foetus is removed, and either DNA is prepared directly ... Genetic heterogeneity Similar phenotypes caused by mutations in more than one gene. ... Locus heterogeneity see genetic heterogeneity...
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Genetic variability and antigenic diversity of foot-and-mouth disease virus – Domingo, MG, et al. - 1990 ... DnaSP version 3.5. An integrated program for molecular population genetic and molecular evolution analysis – Rozas, Rozas - 1999...
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This supposed genetic homogeneity was a major factor in the establishment of deCODE Genetics, the biotechnology company set up in Iceland in 1996 to map disease genes in the Icelandic population.
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Definition of genetic heterogeneity from the online medical dictionary hosted by mondofacto. ... online medical dictionary | definition of genetic heterogeneity...
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