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Alternate Name(s): Globoid cell leukodystrophy; Galactosylcerebrosidase deficiency; Galactosylcereamidase deficiency ... Krabbe disease is an inherited disorder characterized by a deficiency of the enzyme galactocerebroside beta-galactosidase (galactosylcereamidase). Deficiency of this enzyme causes the death of brain cells, a process that underlies the symptoms ...
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www.nlm.nih.gov/medlineplus/ency/article/001198.htm#Def...
www.nlm.nih.gov/medlineplus/ency/article/001198.htm#Definition
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Information for patients about globoid-cell leukodystrophy (Krabbe disease) and bone marrow or cord blood transplant (BMT) as a treatment option. ... Definition of globoid-cell leukodystrophy...
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www.marrow.org/PATIENT/Undrstnd_Disease_Treat/Lrn_about...
www.marrow.org/PATIENT/Undrstnd_Disease_Treat/Lrn_about_Disease/Metabolic_Storage/GLD_and_Tx/index.html
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Krabbe disease - Wikipedia, the free encyclopedia
Krabbe disease (also known as globoid cell leukodystrophy or galactosylceramide lipidosis ) is a rare, often fatal degenerative disorder that affects the myelin sheath of the nervous system. This...
en.wikipedia.org/wiki/Krabbe_disease
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It is characterized by the presence of globoid cells (cells that have more than one nucleus), the breakdown of the nerve’s protective myelin coating, and destruction of brain cells. Krabbe disease is one of a group of genetic disorders called the leukodystrophies. ... United Leukodystrophy Foundation;
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www.ninds.nih.gov/disorders/krabbe/krabbe.htm
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Another name for Krabbe Disease is Globoid Cell Leukodystrophy. This name comes from a characteristic pathology of Krabbe Disease, where a specific type of cell (called the macrophage) accumulates high levels of undegraded galactolipids as a result of the lack of GALC activity.
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www.ulf.org/types/krabbe.html
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Krabbe disease — Comprehensive overview covers symptoms, causes, treatment of this central nervous system disorder. ... Medical Services | Health Information | Appointments | Education and Research | Jobs | About ... When to seek medical advice...
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www.mayoclinic.com/health/krabbe-disease/DS00937
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BACKGROUND AND PURPOSE: Our purpose was to determine the characteristic MR features of early-onset (before age 2 years) versus late-onset (after age 2 years) globoid cell leukodystrophy (GLD).
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www.ajnr.org/cgi/content/full/20/2/316
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Infantile globoid cell leukodystrophy (GLD, or Krabbe disease) is a rare, inherited degenerative disorder of the central and peripheral nervous systems. It is characterized by the presence of globoid cells (multinucleated cells), the breakdown of the nerve's protective myelin coating, and destruction of brain cells.
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clinicaltrials.gov/ct2/show/NCT00983879
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Choice of umbilical cord blood for haematopoietic stem cell transplantation, therefore, requires consideration not only of cell quantity and HLA compatibility but also selection for normal alleles to obtain maximal enzymatic activity for central nervous system correction.
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www.medscape.com/medline/abstract/16435193
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