A intermediate level expository answer to the question: Are mutations harmful? ... Q: Doesn't evolution depend on mutations and aren't most mutations harmful?
www.talkorigins.org/faqs/mutations.html www.talkorigins.org/faqs/mutations.html
coli found that about 1 in 150 newly arising mutations and 1 in 10 functional mutations are beneficial (Perfeito et al. 2007). The harmful mutations do not survive long, and the beneficial mutations survive much longer, so when you consider only surviving mutations, most are beneficial.
www.talkorigins.org/indexcc/CB/CB101.html
There are many examples in nature that show how mutations are beneficial or harmful in the context of their environment. A beneficial or neutral mutation can quickly become harmful when the environments change.
natureniche.tripod.com/mutation.html natureniche.tripod.com/mutation.html
Question: When can mutations be considered helpful? Amanda E Kulik Answer: Mutations are considered helpful if they lead to a trait in the organism ... Remember, you can't make this judgement at the time the mutation occurred, because the environment may change and the silent, non-harmful mutation might then become helpful.
www.newton.dep.anl.gov/askasci/bio99/bio99353.htm
Another thing to keep in mind is that some gene mutations may be harmful in some situations and beneficial in others. Imagine a person with a blood clotting gene who also has a bleeding disease such as hemophilia.
www.newton.dep.anl.gov/askasci/mole00/mole00468.htm
A intermediate level expository answer to the question: Are mutations harmful? ... Abstract; Aren't most mutations harmful; Are there any favorable mutations?; Don't mutations reduce specificty?; Types of mutation and their effects; Mutation Studies by Joe Boxhorn; Notes; Appendix I - mutation rates;
www.tiac.net/~cri/1996/mutate.html www.tiac.net/~cri/1996/mutate.html
Mutations Aren't Always Harmful ... In addition, many of the mechanisms of mutation are understood including mutations that can lead to drastic changes in an organism. This means we understand some of the mechanisms by which changes in an organism can be affected.
atheism.about.com/library/FAQs/evolution/blfaq_evolutio... atheism.about.com/library/FAQs/evolution/blfaq_evolution_evidence04.htm
Kondrashov, A. S. 1982. Selection against harmful mutations in large sexual and asexual populations, Genetical Research, Cambridge 40, 325--332. ... Kondrashov, A. S. 1982. Selection against harmful mutations in large sexual and asexual populations, Genetical Research, Cambridge 40, 325--332. Online articles have much...
citeseer.ist.psu.edu/context/993996/0
Evidence for Inefficient Selection Against Deleterious Mutations in Cytochrome Oxidase I of Asexual Bdelloid Rotifers. T. G. Barraclough, D. Fontaneto, C. Ricci, and E. A. Herniou (2007); Mol. Biol. Evol. 24, 1952-1962 ;
www.sciencemag.org/cgi/content/short/311/5763/990
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