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Clinical healing and resolution of symptoms positively correlated with a higher pretreatment maximum anal resting pressure in the mid anal canal (P < 0.0001), lower fissure score (P < 0.0001), and greater percentage reduction of the maximum resting pressure after application of glyceryl trinitrate (P < 0.001).
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www.medscape.com/medline/abstract/15793649
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PURPOSE: Local application of exogenous nitric oxide donors, such as isosorbide dinitrate and glyceryl trinitrate, promotes fissure healing by reducing anal resting pressure and improving anodermal blood flow. ... After 12 weeks of treatment complete fissure healing was observed in 3 of 13 (23 percent) patients,
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www.medscape.com/medline/abstract/15747070
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This dual effect results in fissure healing in more than 80% of patients. The principal side effect is headaches in 20%-100% of cases. ... Fissure healing occurs in more than 60% of patients. The principal side effect is incontinence of flatus and or feces, which last for up to two months in 2% to 21% of cases.
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www.hemorrhoid.net/fissure.php
www.hemorrhoid.net/fissure.php
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Shed those excess pounds. The more weight you carry, the more you're likely to sweat. Perspiration between the cheeks of your rump will only slow your fissures' healing, says Dr. Lawder. ... Facial tissues coated with moisturizing lotion offer the least amount of friction to your fissure-plagued bottom, says Dr. Lawder.
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www.mothernature.com/Library/Bookshelf/Books/47/59.cfm
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Diet & Fitness ... Mind & Mood ... 5 Healing Juice Drinks...
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health.yahoo.com/ate/drweil/alldaily/2004/03/20040305
health.yahoo.com/ate/drweil/alldaily/2004/03/20040305
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Sitz baths may help relieve discomfort and promote healing. A sitz bath is soaking the anal area in plain warm, not hot, water for 15-20 minutes several times a day. If the fissure is not responding to treatment, the physician re-examines the patient.
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www.gicare.com/diseases/Anal-fissure.aspx
www.gicare.com/diseases/Anal-fissure.aspx
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A fissure is a tear or ulcer in the lining of the anal canal. The anal canal is the last part of the rectum before the ... One new non-surgical method being researched for use in healing fissures is Botox (botulism toxin) injections. The injections work by weakening the anal muscles and thereby allow them to heal.
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ibdcrohns.about.com/cs/relatedconditions/a/fissurefaq.h...
ibdcrohns.about.com/cs/relatedconditions/a/fissurefaq.htm
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Dr. Sohn’s work has been supported by other studies, including a prospectively randomized controlled trial published in January 2008. In this trial fissure-healing rates at six weeks after the operation were 83% in the dilatation group and 92% in the sphincterotomy group, but the rate of postoperative anal...
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www.colonandrectalsurgeons.com/AnalFissure.html
www.colonandrectalsurgeons.com/AnalFissure.html
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Topical application of artificial NO precursors, such as isosorbide dinitrate (ISDN), has been shown to promote fissure healing but is accompanied by frequent and sometimes severe headaches. The researchers hypothesized that because it is naturally present in the body, L-arginine might be free of headache risk.
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www.pslgroup.com/dg/215956.htm
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