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These analyses identified conserved residues critical to HAT activity and demonstrated the direct correlation of Gcn5 HAT function with cell growth, in vivo transcription, and histone acetylation at the Gcn5-dependent HIS3 promoter in vivo (134, 256). A further study with some of these mutants showed that Gcn5's...
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mmbr.asm.org/cgi/content/full/64/2/435
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Using a cell-free system to reconstitute chromatin with increased histone acetylation levels, we directly tested for a causal role of histone acetylation in transcription by RNA pol II.
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www.nature.com/emboj/journal/v17/n10/abs/7590994a.html
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Here we show that transcriptional regulation of the core clock mechanism in mouse liver is accompanied by rhythms in H3 histone acetylation, and that H3 acetylation is a potential target of the inhibitory action of Cry. ... Moreover, the Cry proteins inhibit a p300-induced increase in Clock/Bmal1-mediated transcription.
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www.nature.com/nature/journal/v421/n6919/full/nature013...
www.nature.com/nature/journal/v421/n6919/full/nature01314.html
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The authors describe the use of Drosophila model in demonstrating that polygmutamine-induced neurodegeneration is caused by a defect in histone acetylation and transcription profile alteration...
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www.faqs.org/abstracts/Biological-sciences/Abberrant-hi...
www.faqs.org/abstracts/Biological-sciences/Abberrant-histone-acetylation-altered-transcription-and-retinal-degeneration-in-a-Drosophila-model-o.html
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The stimulatory effect of TAF-Iß decreased when the model gene transcription was sufficiently stimulated by a high level of histone acetylation or the transcription activator TetR-VP16 (data not shown). Based on these results, it is presumed that TAF-I is associated with genes expressed at an intrinsically low level.
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nar.oxfordjournals.org/cgi/content/full/35/3/705
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On performing an experiment with a cell line containing a model gene integrated into the chromosome, TAF-I was found to stimulate the model gene transcription in a histone chaperone activity-dependent manner additively with histone acetylation.
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nar.oxfordjournals.org/cgi/content/abstract/35/3/705
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Recent studies implicate the transcription factor E2A in Ig diversification such as somatic hypermutation or gene conversion (GCV). GCV also requires active Ig ... Thus, E2A may contribute to GCV by maintaining histone acetylation, which could be a prerequisite for targeting or full deaminase function of AID.
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intimm.oxfordjournals.org/cgi/content/abstract/20/2/277
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We have previously identified template-activating factor-Iß (TAF-Iß, also called PHAPII, SET, and I2pp2A) as a component of a cellular complex called inhibitor of acetyltransferases (INHAT) that masks histone acetylation in vitro and blocks histone acetyltransferase (HAT)-dependent transcription in living cells.
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mend.endojournals.org/cgi/content/full/20/2/335
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K. Kato, M. Miyaji-Yamaguchi, M. Okuwaki, and K. Nagata; Histone acetylation-independent transcription stimulation by a histone chaperone; Nucleic Acids Res., February 16, 2007; 35(3): 705 - 715. [Abstract] [Full Text] [PDF];
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mend.endojournals.org/cgi/content/abstract/20/2/335
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