Preventive Treatment for Sickle Cell Disease Hydroxyurea became the first (and only) drug proven to prevent complications of sickle cell disease in the Multicenter Study of Hydroxyurea in Sickle Cell Anemia which was completed in 1995. For more information, see "Hemoglobin: molecular, genetic, and clinical aspects",
sickle.bwh.harvard.edu/scd_history.html sickle.bwh.harvard.edu/scd_history.html
Brief History of Sickle Cell Disease; Hemoglobin Basics; Hemoglobin Synthesis; How Does Sickle Cause Disease?; Sickle Syndrome Definitons; How Do People Get Sickle Cell Disease?; Why is Sickle Cell Disease so Variable?; Malaria and The Red Cell; Sickle Cell Disease in India; Sickle Cell Disease in Cuba; Sickle Cell Trait;
sickle.bwh.harvard.edu/menu_sickle.html sickle.bwh.harvard.edu/menu_sickle.html
Although the HbS gene is most common in Africa, sickle cell disease went unreported in African medical literature until the 1870s. This may be because the symptoms were similar to those of other tropical diseases in Africa and because blood was not usually examined.
www.innvista.com/health/ailments/anemias/sickhist.htm www.innvista.com/health/ailments/anemias/sickhist.htm
Watch Giovanna Poli talk about herself and Sickle Cell Disease on Youtube; "President Obama greets SCDAA 2008 National Poster Child"; As part of SCDAA’s continued goal of advocating on behalf of those with Sickle Cell Disease, we have a champion in the White House.
www.sicklecelldisease.org/ www.sicklecelldisease.org/
Sickle cell anemia was the first diagnosed disease that was linked to the hemoglobin protein and genetically characterized. Pauling’s new hypothesis together with the old stated that the sickling of the cells in sickle cell anemia may be due to the formation of "rods" by the hemoglobin and thus "sickle" the cell (Johnson,
biology.kenyon.edu/slonc/gene-web/sickle_cell_project/H... biology.kenyon.edu/slonc/gene-web/sickle_cell_project/History.html
For more about the gene that causes sickle cell anemia, see the HBB Gene Profile. The following was adapted from NIH Publication No. 96-4057. ... 1949 - Noted physical chemist Linus Pauling and associates publish "Sickle Cell Anemia, a Molecular Disease" in Science. This paper explains how protein electrophoresis was used...
www.ornl.gov/sci/techresources/Human_Genome/posters/chr... www.ornl.gov/sci/techresources/Human_Genome/posters/chromosome/sca.shtml
Sickle-cell disease - Wikipedia, the free encyclopedia
Sickle-cell disease , or sickle-cell anaemia (or drepanocytosis ), is a life-long blood disorder characterized by red blood cells that assume an abnormal, rigid, sickle shape. Sickling decreases ...
en.wikipedia.org/wiki/Sickle-cell_disease
History of Sickle Cell Disease; ... 1910 Herrick described sickled cells in the blood of a dental student. The term sickle cell anemia was used because of the “sickled” shape of the blood cell.
www.parentsagainstcancer.com/sickle_cell.htm www.parentsagainstcancer.com/sickle_cell.htm
Sickle Cell Anemia - History of Sickle Cell Anemia from The Oxford Companion to United States History at Encyclopedia.com ... Todd L. Savitt , The Invisible Malady: Sickle Cell Anemia in America, 1910–1970, Journal of the National Medical Association 73 (1981), 739–746. Keith Wailoo , Drawing Blood:
www.encyclopedia.com/doc/1O119-SickleCellAnemia.html www.encyclopedia.com/doc/1O119-SickleCellAnemia.html
The symptoms include: family history of sickle cell anemia, fatigue, breathlessness, rapid heart rate, delayed growth and puberty, susceptibility to infections, ulcers on the lower legs (in adolescents and adults) jaundice, attacks of abdominal pain, weakness, joint pain, fever, vomiting,
www.mamashealth.com/sickle_cell.asp www.mamashealth.com/sickle_cell.asp