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The present study was performed to evaluate the role of an interaction between ET and RAS in the development of hypertension and hypertension-associated end-organ damage in homozygous male transgenic rats harboring the mouse Ren-2 renin gene (TGRs) under conditions of normal-salt (NS, 0.45% NaCl) and high-salt (HS,
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www.karger.com/doi/10.1159/000080052
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From a population survey, in 184 patients with mild hypertension (4 times systolic blood pressure 160 mm Hg and/or diastolic blood pressure 95 mm Hg), 60 to 75 years of age, cardiovascular end-organ damage was measured.
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hyper.ahajournals.org/cgi/content/full/hypertensionaha;...
hyper.ahajournals.org/cgi/content/full/hypertensionaha;37/4/1083
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Angiotensin II (Ang II)–mediated hypertension causes end-organ damage not only via increased blood pressure but also via the direct effects of Ang II. ... Homozygous Ren2 rats show severe hypertension throughout the study as measured by tail-cuff. Imatinib treatment did not affect systolic blood pressure. *P<0.05;
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hyper.ahajournals.org/cgi/content/full/47/3/467
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The possible involvement of androgen receptors in the development of hypertension and end-organ damage in transgenic rats harboring the mouse Ren-2 renin gene [TGR(mREN2)27] was studied. Male TGR(mREN2 ... Untreated TGR(mREN2)27 rats developed fulminant hypertension starting at 10 wk of age as measured by telemetry (Figure 2).
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jasn.asnjournals.org/cgi/content/full/13/11/2681
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Hypertension and Associated End Organ Damage ... These data provide the first opportunity to study the relationships between a large number of cardiovascular phenotypes measured within each animal in a genomic context by the assignment of cardiovascular physiology onto the genome.
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www.nhlbi.nih.gov/meetings/ish/h_jacob.htm
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The purpose of this study was to further illustrate the relationship between baroreceptor reflex sensitivity (BRS) and hypertensive end-organ damage (EOD) and to test the hypothesis that impairment of BRS aggravates EOD in hypertension.
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ajpheart.physiology.org/cgi/content/full/277/3/H1200
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Not only can the mean systolic and diastolic BP be measured, the percentage of elevated readings and awake to sleeping decline can be assessed. In addition, there is a need for more sensitive markers of target organ damage. ... End organ damage in children with primary hypertension...
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crisp.cit.nih.gov/crisp/CRISP_LIB.getdoc?textkey=691972...
crisp.cit.nih.gov/crisp/CRISP_LIB.getdoc?textkey=6919728&p_grant_num=1K23HL083910-01A2&p_query=&ticket=17223926&p_audit_session_id=80829171&p_keywords=
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Conclusions— These results demonstrate a crucial role for p38 MAPK in hypertensive cardiac hypertrophy and end-organ damage. Interrupting its function with ... By use of the leading-edge method,22 systolic and diastolic thicknesses of the anterior and posterior walls and the left ventricular (LV) diameter were measured.
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circ.ahajournals.org/cgi/content/full/104/11/1292
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These complications of hypertension are often referred to as end-organ damage because damage to these organs is the end result of chronic (long duration) high blood pressure. For that reason, the diagnosis of high blood pressure is important so efforts can be made to normalize ... How is the blood pressure measured?
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www.medicinenet.com/high_blood_pressure/article.htm
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