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Hyperbilirubinemia is one of the most common problems encountered in term newborns. Historically, management guidelines were derived from studies on bilirubin toxicity in infants with hemolytic disease. More recent recommendations support the use of less intensive therapy in healthy term newborns with jaundice.
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www.aafp.org/afp/20020215/599.html
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Common causes of hyperbilirubinemia include premature birth, ABO and Rh blood-type incompatibility and peripartum infection. The authors recommend using a percentile-based nomogram to predict which infants are at highest risk of severe hyperbilirubinemia.
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www.aafp.org/afp/20010915/tips/15.html
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Conjugated hyperbilirubinemia results from reduced secretion of conjugated bilirubin into the bile, such as occurs in patients with hepatitis, or it results from impaired flow of bile into the intestine, such as occurs in patients with biliary obstruction.
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emedicine.medscape.com/article/178757-overview
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Drugs/contrast agents: Unconjugated hyperbilirubinemia due to drugs/contrast agent resolves within 48 hours of discontinuing the drug. ... In a study of genetic risk factors in 35 breast-fed term infants with prolonged unconjugated hyperbilirubinemia, Chang et al examined the prevalence in these neonates of known variant...
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emedicine.medscape.com/article/178841-overview
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Jaundice - Wikipedia, the free encyclopedia
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Jaundice , also known as icterus (attributive adjective: icteric ), is a yellowish discoloration of the skin, the conjunctival membranes over the sclerae (whites of the eyes), and other mucous me...
en.wikipedia.org/wiki/Jaundice
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Hyperbilirubinemia is an abnormally high level of bilirubin (a pigment produced from the breakdown of red blood cells) in the blood. ... Severe hyperbilirubinemia is usually caused by illnesses that interfere with feeding, serious disorders such as sepsis, or the rapid breakdown of red blood cells.
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www.merck.com/mmhe/sec23/ch264/ch264p.html
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Transient familial hyperbilirubinemia is a metabolic disorder passed down through families. Babies with this disorder are born with severe jaundice. ... Transient familial hyperbilirubinemia is thought to be an autosomal recessive inherited disorder. It occurs when the body does not properly break down (metabolize) a...
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www.nlm.nih.gov/medlineplus/ency/article/001196.htm
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Most jaundice is benign, but because of the potential toxicity of bilirubin, newborn infants must be monitored to identify those who might develop severe hyperbilirubinemia and, in rare cases, acute bilirubin encephalopathy or kernicterus.
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aappolicy.aappublications.org/cgi/content/full/pediatri...
aappolicy.aappublications.org/cgi/content/full/pediatrics;114/1/297
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