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The 2 mg bolus i.v. injection of ibandronate was well tolerated. Most AEs were mild, temporary and manageable, only one patient withdrawing as a result of a treatment-related side-effect. In total, 19.2% of patients receiving ibandronate and 17.3% of those treated with alfacalcidol discontinued the study early.
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rheumatology.oxfordjournals.org/cgi/content/full/42/6/7...
rheumatology.oxfordjournals.org/cgi/content/full/42/6/743
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Three-monthly i.v. ibandronate bolus injections are significantly superior to alfacalcidol in the treatment of CIO. These data confirm the potential of ibandronate for the treatment of osteoporosis associated with corticosteroid use.
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rheumatology.oxfordjournals.org/cgi/content/abstract/42...
rheumatology.oxfordjournals.org/cgi/content/abstract/42/6/743
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; When giving an I.V. bolus injection, keep these considerations in mind: ... Don't give a drug by I.V. bolus injection if you need to dilute it in a large-volume parenteral solution before it enters the bloodstream. ... Avoid using an I.V. bolus injection whenever the rapid administration of a drug, such as potassium...
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www.edruginfo.com/cp_givinganivbolusinjection.htm
www.edruginfo.com/cp_givinganivbolusinjection.htm
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Comparison of intravenous bolus injection or continuous infusion of recombinant single chain urokinase-type plasminogen activator (saruplase) for thrombolysis. A canine model of combined coronary arterial ... Placebo infusion (group V) was associated with late recanalization in 1 of 5 dogs and 18 +/- 8% venous clot lysis.
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www.bloodjournal.org/cgi/content/abstract/76/8/1558
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S.A., Loupoigne, Belgium) after an IV bolus injection or infusion of the free or DNA-bound drug ..... Administration of DOX-DNA by either IV bolus injection ...
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www.springerlink.com/index/U2142862L2W3791J.pdf
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To understand the difference in interference with cisplatin-induced antitumour activity between BNP7787 and mesna as well to characterise the selective nephroprotection by BNP7787, the pharmacokinetics of BNP7787 and mesna, each given i.v. 1000 mg x kg(-1), were determined in plasma, kidney, liver, red blood cells...
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www.druglib.com/abstract/ve/verschraagen-m_br-j-cancer_...
www.druglib.com/abstract/ve/verschraagen-m_br-j-cancer_20040419.html
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[INTRAVENOUS INFUSION, DILUTED WITH STERILE WATER FOR INJECTION]; (not for IV Bolus Injection); RX ONLY; ERAXIS™ (anidulafungin) FOR INJECTION; DESCRIPTION; ERAXIS for Injection is a sterile, lyophilized product for intravenous (IV) infusion that contains anidulafungin.
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www.pfizer.com/files/products/uspi_eraxis.pdf
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Methods and Results In 33 patients, hemodynamic parameters were measured after oxygen inhalation and during bolus injection of nonionic contrast medium in a control group (group 1, n=11), in a group of patients with moderately severe pulmonary hypertension (group 2, n=9), and in a group with severe pulmonary...
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circ.ahajournals.org/cgi/content/full/94/10/2485
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Fig 4.5.1 Slide of body before and after a rapid IV bolus injection, considering the body to behave as a single compartment. In order to simplify the mathematics it is often possible to assume that a drug given by rapid intravenous injection, a bolus, is rapidly mixed.
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www.boomer.org/c/p3/c04/c0405.html
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