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Unpredictable, nonimmune drug reactions can be classified as pseudoallergic, idiosyncratic, or intolerance. Pseudoallergic reactions are the result of direct mast cell activation and degranulation by drugs such as opiates, vancomycin (Vancocin), and radiocontrast media.
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www.aafp.org/afp/20031101/1781.html
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Idiosyncratic adverse reactions are not related to the known ..... Pathogenesis of hypersensitivity reactions to drugs in patients with HIV infection --- ...
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bmj.bmjjournals.com/cgi/content/full/316/7140/1295
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For example, many drugs that form reactive metabolites, such as paracetamol, are not associated with a high incidence of idiosyncratic reactions. ...
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linkinghub.elsevier.com/retrieve/pii/S0140673600031378
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Genetic basis for idiosyncratic reactions to antiepileptic drugs. ... This article will focus on recent findings concerning genetic factors affecting susceptibility to idiosyncratic reactions to antiepileptic drugs.
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www.ncbi.nlm.nih.gov/pubmed/19262378
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pt.wkhealth.com/pt/re/nursing/pdfhandler.00019052-20090...
pt.wkhealth.com/pt/re/nursing/pdfhandler.00019052-200904000-00006.pdf
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Idiosyncratic reactions are unpredictable and not explained by the pharmacologic properties of the drug. An example is the individual with infectious mononucleosis who develops a rash when given ampicillin. ... Document any history of previous adverse reactions to drugs or foods. Consider alternative etiologies,
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emedicine.medscape.com/article/1049474-overview
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Idiosyncratic reactions are a major source of concern because they encompass most life-threatening effects of antiepileptic drugs (AEDs), as well as many other reactions requiring discontinuation of treatment.
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www.medscape.com/medline/abstract/17386054
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Type A reactions can usually be recognized as common adverse effects reported on drug labeling (Table 2). Conversely, type B reactions are not related to the known pharmacologic effects of a drug and are dose independent (even occurring at miniscule doses), unpredictable, idiosyncratic, often serious, and account for...
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pediatrics.aappublications.org/cgi/content/full/120/4/e...
pediatrics.aappublications.org/cgi/content/full/120/4/e1082
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Titre du document / Document title ... Affiliation(s) du ou des auteurs / Author(s) Affiliation(s) ... Revue / Journal Title...
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cat.inist.fr/?aModele=afficheN&cpsidt=869153
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