Patients who lack, or have very low levels of, one or two IgG subclasses, but whose other immunoglobulin levels are normal, are said to have a selective IgG subclass deficiency. While all the IgG subclasses contain antibodies, each subclass serves somewhat different functions in protecting the body against infection.
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www.immunedisease.com/patients-and-families/about-pi/ty...
www.immunedisease.com/patients-and-families/about-pi/types-of-pi/igg-subclass-deficiency.html
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Site funding provided by: The Immune Deficiency Foundation is the National Patient Organization Dedicated to Improving the Diagnosis, Treatment and Quality of Life of Persons with Primary Immunodeficiency Diseases through Advocacy, Education, and Research In the News...
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These concomitant immune defects may include deficiencies of certain IgG subclasses or of mannose-binding lectin (MBL).2 The most common IgG-subclass deficiency associated with IgA deficiency is that of IgG2. IgA-IgG2 deficiency can also be seen with other IgG-subclass deficiencies, especially that involving IgG4.
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emedicine.medscape.com/article/885348-overview
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2.3 Properties of human IgG subclasses 2.4 Antibody activity of IgG subclasses 2.5 + 2.5.1 + 2.5.2 Effector functions of IgG subclasses ; Complement activation ; Opsonisation and induction of phagacytosis...
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www.researchd.com/rdikits/rdisubbk.htm
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There are four IgG subclasses (IgG1, 2, 3 and 4) in humans, named in order of their abundance in serum (IgG1 being the most abundant).
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en.wikipedia.org/wiki/Immunoglobulin_G
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compendium of facts regarding the human IgG subclasses. First, physical, chemical, and biological properties of the human IgG subclasses are summa-
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www.antibodybeyond.com/books/Calbiochem_Human_IgG_Bookl...
www.antibodybeyond.com/books/Calbiochem_Human_IgG_Booklet_CB0051.pdf
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Figure 3 demonstrates recognition by IgG subclasses of adult extracts of P. westermani. The sera from patients infected with P. westermani and P. miyazakii reacted mainly to both 32- and 35-kDa bands with IgG4 (18 of 20 [90%] for patients with P. westermani paragonimiasis;
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cdli.asm.org/cgi/content/full/5/4/474
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Recombinant versions of the seven equine IgG subclasses were expressed in CHO cells. All assembled into intact immunoglobulins stabilised by disulphide bridges, although, reminiscent of human IgG4, a small proportion of equine IgG4 and IgG7 were held together by non-covalent bonds alone.
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ukpmc.ac.uk/articlerender.cgi?tool=pmcentrez&accid=pmcA...
ukpmc.ac.uk/articlerender.cgi?tool=pmcentrez&accid=pmcA2075531
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Antibody-mediated Modulation of Cryptococcus neoformans Infection Is Dependent on Distinct Fc Receptor Functions and IgG Subclasses; RuiRong Yuan*, Raphael Clynes , Jin Oh*, Jeffrey V. Ravetch , and Matthew D. Scharff*
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jem.rupress.org/cgi/content/abstract/187/4/641
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