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The ischemic penumbra represents part of the hypoperfused region associated with focal brain ischemia. Various definitions for the ischemic penumbra have been proposed, but a practical approach is to define this region as that portion of the ischemic territory that can potentially be salvaged by timely intervention.
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www.kenes.com/stroke5/Abstracts/114.htm
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The term ischemic penumbra, originally applied to brain tissue perfused at values between the functional and morphologic thresholds, has recently been extended to characterize ischemically affected but still viable tissue with uncertain chances for infarction or recovery.
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www.ionchannels.org/showabstract.php?pmid=8173671
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Definition of ischemic penumbra in the Medical Dictionary. ischemic penumbra explanation. Information about ischemic penumbra in Free online English dictionary. What is ischemic penumbra? Meaning of ischemic penumbra medical term. ... As described, there is an ischemic penumbra around poorly oxygenated brain cells.
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medical-dictionary.thefreedictionary.com/ischemic+penum...
medical-dictionary.thefreedictionary.com/ischemic+penumbra
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The concept of the ischemic penumbra is now more than 20 years old and has become increasingly important as the potential for treating acute ischemic stroke expands.
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stroke.ahajournals.org/cgi/content/full/35/11_suppl_1/2...
stroke.ahajournals.org/cgi/content/full/35/11_suppl_1/2657
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WKY). Study aims were to investigate temporal changes in the ischemic penumbra in SHRSP compared with WKY. ... Conclusions—First, SHRSP have significantly more ischemic damage and a smaller penumbra than do WKY within 1 hour of stroke; second, the penumbra is recruited into the ADC abnormality over time in both strains;
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stroke.ahajournals.org/cgi/content/abstract/STROKEAHA.1...
stroke.ahajournals.org/cgi/content/abstract/STROKEAHA.109.559021v1
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The Ischemic Penumbra: Identification, Evolution and Treatment Concepts; Marc Fisher; Department of Neurology, University of Massachusetts Medical School, Worcester, Mass., USA; ... Currently, three main challenges persist for those interested in the ischemic penumbra concept: how can this ischemic region be most...
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www.karger.com/doi/10.1159/000074790
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Differences in the Evolution of the Ischemic Penumbra in Stroke-Prone Spontaneously Hypertensive and Wistar-Kyoto Rats; Stroke, December 1, 2009; 40(12): 3864 - 3868. [Abstract] [Full Text] [PDF];
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www.neurology.org/cgi/content/abstract/53/7/1528
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CONCLUSIONS: Despite a prominent increase in ICP and MAP after ICH, the authors found no evidence to support the presence of an ischemic penumbra in the first 5 hours after ICH. Thus, other mechanisms for acute neural injury and late rCBF changes after ICH must be investigated.
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www.neurology.org/cgi/content/abstract/52/2/266
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The Concept of Ischemic Penumbra in Acute Stroke and Therapeutic Opportunities; Maurizio Paciaroni, Valeria Caso, Giancarlo Agnelli; Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy;
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www.karger.com/doi/10.1159/000210544
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