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The gold standard for limb regeneration is the salamander, which can grow perfect replacements for lost body parts throughout its lifetime. Understanding how can provide a road map for human limb regeneration.
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www.scientificamerican.com/article.cfm?id=regrowing-hum...
www.scientificamerican.com/article.cfm?id=regrowing-human-limbs
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© University of California Irvine 2006 University of California Irvine, limb regeneration, Developmental and Cell Biology, stem cells, toxicology, teratology, endocrine disruption, DAPI stained cells, axolotl, nuclear, microscopic view, deformed frogs University of California Irvine, limb regeneration,
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regeneration.bio.uci.edu/
regeneration.bio.uci.edu/
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Citations: “Cells keep a memory of their tissue origin during axolotl limb regeneration.” By Martin Kragl, Dunja Knapp, Eugen Nacu, Shahryar Khattak, Malcolm Maden, Hans Henning Epperlein & Elly M. Tanaka. Nature, Vol.
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www.wired.com/wiredscience/2009/07/regeneration/
www.wired.com/wiredscience/2009/07/regeneration/
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The basics of limb regeneration have been evident for more than a century. First, the animal heals the wound at the site of the missing limb. Then, various specialized cells at the site, such as bone, skin, and blood cells, lose their identity in a process called dedifferentiation.
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www.sciencenews.org/sn_arc97/11_1_97/bob1.htm
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mphibians have the unique capability to regenerate limbs -- and zoology professor Steven Scadding has dedicated his 25-year research career to finding out why. His is one of only a dozen laboratories in the world studying the factors that control limb regeneration.
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www.uoguelph.ca/research/publications/Assets/HTML_MAGS/...
www.uoguelph.ca/research/publications/Assets/HTML_MAGS/oasis/evolution3.html
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Manipulating regeneration functionality involved the researchers using inhibitory and excitatory factors for Wnt signaling, which they delivered directly to the site where the limb was removed.
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www.scienceagogo.com/news/20061019233435data_trunc_sys....
www.scienceagogo.com/news/20061019233435data_trunc_sys.shtml
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Researchers at the Université de Montréal have identified a cell signaling pathway implicated in limb regeneration in axolotls. The axolotl is a salamander living in Mexican lakes with ... Researchers at the Université de Montréal have identified a cell signaling pathway implicated in limb regeneration in axolotls.
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www.medicalnewstoday.com/articles/89812.php
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Hope for human limb regeneration was raised last year when a 69-year-old man grew back half an inch of his finger using a extracellular matrix powder made from cells scraped from a pig’s bladder. The powder was given to him by his brother, Dr. Stephen Badylak, who studies regeneration at the University of Pittsburgh.
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www.findingdulcinea.com/news/science/2009/june/Axolotl-...
www.findingdulcinea.com/news/science/2009/june/Axolotl-Salamander-Could-Hold-the-Key-to-Human-Limb-Regeneration.html
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Tulane Receives Grant to Study Limb Regeneration ... "By establishing a comprehensive database that identifies all the genes involved in regenerating a salamander limb, we will essentially create a genetic blueprint of how to do the same in humans."
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tulane.edu/news/releases/tulane-receives-grant-for-limb...
tulane.edu/news/releases/tulane-receives-grant-for-limb-regeneration.cfm
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