A term used in those genetic conditions where a single syndrome is caused by different genes in different families, possibly due to the different environmental factors that have influenced them.
http://wiki.answers.com/Q/What_is_locus_heterogeneity
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Heterogeneity - Wikipedia, the free encyclopedia
Heterogeneous is an adjective used to describe an object or system consisting of multiple items having a large number of structural variations. It is the opposite of homogeneous , which means that ...
en.wikipedia.org/wiki/Heterogeneity
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Our results demonstrate that there is locus heterogeneity of this disorder; therefore, mutations in at least two different genes can give rise to the ADO phenotype. ... Locus Heterogeneity of Autosomal Dominant Osteopetrosis (ADO)1...
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jcem.endojournals.org/cgi/content/full/84/3/1047
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Locus heterogeneity poses a major difficulty in mapping genes that influence complex genetic traits. A widely used approach to deal with this problem involves modeling linkage data in terms of finite mixture distributions.
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www.biomedcentral.com/1471-2156/5/29
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Original Article from The New England Journal of Medicine -- Linkage of a gene causing familial amyotrophic lateral sclerosis to chromosome 21 and evidence of genetic-locus heterogeneity ... T Siddique, DA Figlewicz, MA Pericak-Vance, JL Haines, G Rouleau, AJ Jeffers, P Sapp, ... This article has been cited by other articles:
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content.nejm.org/cgi/content/abstract/324/20/1381
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However, significant evidence for linkage was detected in the presence of locus heterogeneity using the admixture test (odds ratio, 15, 135:1). The estimated proportion of linked families within the 53 families examined varied between 0.40 and 0.65, depending on the genetic model assumed and APOE status.
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jama.ama-assn.org/cgi/content/abstract/280/7/614
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Allelic and locus heterogeneity in inherited venous malformations; Introduction; Results; Clinical description of families; Allelic heterogeneity for VM; Ligand-independent hyperphosphorylation for R849W and Y897S mutants;
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hmg.oxfordjournals.org/cgi/content/full/8/7/1279
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Automatic download; [Begin manual download] ... Downloading the PDF version of:; Hum. Mol. Genet. Calvert et al. 8 (7): 1279. (616K) ... This file is in Adobe Acrobat (PDF) format. If you have not installed and configured the Adobe Acrobat Reader on your system, see Help with Printing for instructions.
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hmg.oxfordjournals.org/cgi/reprint/8/7/1279
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The situation in which mutations in genes at different chromosomal loci cause the same phenotype ... Related Terms: allele; allelic heterogeneity; genotype; locus; mutation; phenotype...
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www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=g...
www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=glossary&rendertype=def-item&id=locus-heterogeneity
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