Macula densa - Wikipedia, the free encyclopedia
In the kidney, the macula densa is an area of closely packed specialized cells lining the wall of the distal tubule at the point of return of the nephron to the vascular pole of its parent glomerulu...
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Definition of macula densa from The American Heritage Medical Dictionary. ... Dictionary Home » The American Heritage Medical Dictionary » macula densa...
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The macula densa and the TGF response. ... The epithelial cells at this contact point, the macula densa cells, together with the smooth muscle cells of the afferent arterioles and the renin-secreting granular cells, form a functional unit, the juxtaglomerular apparatus (JGA).
www.jci.org/cgi/content/full/104/8/1007
macula densa ( ′makyələ ′densə ) ( medicine ) A thickening of the epithelium of the ascending limb of the loop of ... Sci-Tech Dictionary: macula densa...
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Definition of macula densa in the Medical Dictionary. macula densa explanation. Information about macula densa in Free online English dictionary. What is macula densa? Meaning of macula densa medical term. What does macula densa mean? ... macula densa; macula flava; macula flava laryngis; macula flava laryngis;
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Definition of macula densa from Merriam-Webster's Medical Dictionary with examples and pronunciations. ... Learn more about "macula densa" ... Learn more about "macula densa" and related topics at Britannica.com...
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Macula densa cells are unique renal biosensor cells that detect changes in luminal NaCl concentration ([NaCl]L) and transmit signals to the mesangial ...
www.pnas.org/content/100/7/4322.abstract
Experiments were performed in neuronal (nNOS)- and endothelial nitric oxide synthase (eNOS)-deficient mice to study the role of nitric oxide (NO) in macula densa control of renin secretion in vivo and in the isolated, perfused mouse kidney.
ajprenal.physiology.org/cgi/content/full/286/5/F848
Luminal addition of 20 mM NH+4 produced a rapid acidification of rabbit macula densa (MD) cells from 7.50 ± 0.06 to 6.91 ± 0.05 at an initial rate of 0.071 ± 0.008 pH unit/s. In the luminal presence of 5 µM bumetanide, 5 mM Ba2+ or both, the acidification rate was reduced by 57%, 35% and 93% of control levels.
ajprenal.physiology.org/cgi/content/full/273/5/F817
The fluid load to the distal tubule is first sensed at the macula densa site via the entry of NaCl, through a Na, K, 2Cl co-transport mechanism. The next step is unclear, but there is recent evidence of an increased macula densa cell calcium concentration with a reduction in fluid load to the macula densa.
www.medscape.com/medline/abstract/15283760?prt=true