|
If you experience any of the following serious side effects, stop taking meperidine and seek emergency medical attention or contact your doctor immediately: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, ...
|
health.yahoo.com/drug/d00017a1#d00017a1-sideeffects
|
|
|
|
In addition, meperidine can precipitate monoamine oxidase inhibitor reactions, and during metabolism it is demethylated to normeperidine, a compound with significant central nervous system (CNS) toxicity. Meperidine should be considered a second line agent in the treatment of pain when opioid analgesics are required.
|
www.ncbi.nlm.nih.gov/pubmed/8747629
|
|
|
Due to this first pass effect, 50-60% of an oral dose is converted directly to toxic meperidine metabolites, specifically nor-meperidine. ...
|
www.paindr.com/meperidine%20guidelines.rtf
www.paindr.com/meperidine%20guidelines.rtf
|
|
|
Danziger LH, Martin SJ, Blum RA. Central nervous system toxicity associated with meperidine use in hepatic disease. Pharmacotherapy. 1994; 14:235-8. ... Clark RF, Wei EM, Anderson PO. Meperidine: therapeutic use and toxicity. J Emerg Med. 1995; 13:797-802.
|
www.medscape.com/viewarticle/557796
|
|
|
The use of meperidine can lead to neuropsychiatric tox icity manifested by excitatory states and seizure. Nor meperidine, an active metabolite, is the agent responsi ble for this toxicity; its long half-life of elimination allows for significant accumulation with repeated dosing of the parent compound.
|
jic.sagepub.com/cgi/content/abstract/3/5/246
|
|
Important Meperidine related drug toxicity information for the patients. ... Physiology Meperidine is a synthetic morpine like compound used in the management of moderate to severe pain and acts as an adjunct to anesthesia and preoperative sedation. ... Medindia » Drug Toxicity » Meperidine...
|
www.medindia.net/drugs/drug_toxicity/meperidine.htm
www.medindia.net/drugs/drug_toxicity/meperidine.htm
|
|
Meperidine: a critical review by; Latta KS, Ginsberg B, Barkin RL. Department of Pharmacy, Duke University Medical Center, Durham, ... Meperidine's poor efficacy, toxicity, and multiple drug interactions have resulted in a movement to replace meperidine with more efficacious and less toxic opioid analgesics.
|
www.opioids.com/meperidine/review.html
www.opioids.com/meperidine/review.html
|
|
Toxicity Meperidine shares the toxic effects of other opioids, including respiratory and circulatory depression. Like other opioids, tolerance to the ...
|
linkinghub.elsevier.com/retrieve/pii/0736467995020020
|
|
Meperidine toxicity cannot be reversed with naloxone, which may in fact be harmful since it will reverse the opioid-induced CNS depression caused by meperidine, while not reversing the CNS excitation caused by normeperidine.
|
cme.health.pitt.edu/articles/Meperidine.html
cme.health.pitt.edu/articles/Meperidine.html
|
|
