The nature of microglia fascinated many prominent researchers in the 19th and early 20th centuries, and in a classic treatise in 1932, Pio del Rio-Hortega formulated a number of concepts regarding the function of these resident macrophages of the brain parenchyma that remain relevant to this day.
cmr.asm.org/cgi/content/full/17/4/942
Microglia - Wikipedia, the free encyclopedia
Microglia are a type of glial cells that are the resident macrophages of the brain and spinal cord, and thus act as the first and main form of active immune defense in the central nervous system (CNS...
en.wikipedia.org/wiki/Microglia
Microglia are the smallest of the glial cells. Some act as phagocytes cleaning up CNS debris. Most serve as representatives of the immune system in the brain. Microglia protect the brain from invading microorganisms and are thought to be similar in nature to microphages in the blood system.
blustein.tripod.com/Microglia/microglia.htm blustein.tripod.com/Microglia/microglia.htm
Microglia are tissue macrophages that populate the mammalian central nervous system (CNS) very early in embryonic development. ... 2)Therefore, microglia are poised to contribute to either the onset, progression OR the resolution and repair observed during neuroinflammatory disease.
www.microglia.org/ www.microglia.org/
This study confirms the importance of microglia as a double-edged sword, and focuses on the importance of targeting microglia to minimize cytotoxicity and maximize neuroprotection in neurodegenerative diseases.
www.medscape.com/medline/abstract/17043238
We examined the neuroprotective role of nicergoline in neuron-microglia or neuron-astrocytes co-cultures. ... We examined the neuroprotective role of nicergoline in neuron-microglia or neuron-astrocytes co-cultures. Nicergoline, an ergoline derivative, significantly suppressed the neuronal cell death induced by co-culture...
www.medscape.com/medline/abstract/16325157
The biology and function of microglia is central to many issues in modern neuropathology. Microglia and brain macrophages have been recognized to play crucial roles in important diseases such as viral infections, autoimmunity and neurodegenerative disorders.
www.microglia.net/ www.microglia.net/
MICROGLIA HOME PAGE ... Important information on Microglia ... Microglia and perivascular macrophages...
www.microglia.net/microglia.htm www.microglia.net/microglia.htm
Microglia make up the innate immune system of the central nervous system and are key cellular mediators of neuroinflammatory processes. Their role in central nervous system diseases, including infections, is discussed in terms of a participation in both acute and chronic neuroinflammatory responses.
www.jneuroinflammation.com/content/1/1/14
Microglia in normal human brain can be specifically demonstrated using ... Recognition of microglia cell in a ramified (resting) or ameboid (active) state. ...
www.uaf.edu/chem/451f00D/Microglia.ppt www.uaf.edu/chem/451f00D/Microglia.ppt