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Perspective from The New England Journal of Medicine -- Microsatellite Instability ... Microsatellites are stretches of DNA in which a short motif (usually one to five nucleotides long) is repeated several times. A typical mononucleotide-repeat microsatellite might be, for instance, a stretch of 13 adenines, abbreviated (A)13.
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content.nejm.org/cgi/content/extract/349/3/209
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Original Article from The New England Journal of Medicine -- Tumor Microsatellite-Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for Colon Cancer ... Results Of 570 tissue specimens, 95 (16.7 percent) exhibited high-frequency microsatellite instability.
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content.nejm.org/cgi/content/abstract/349/3/247
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AIM: To study the frequency of microsatellite instability (MSI) and loss of heterozygosity (LOH) in areas of chronic gastritis and intestinal metaplasia in gastric biopsies of patients without cancer.
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www.medscape.com/medline/abstract/15022398
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We report on the establishment of a new scirrhous gastric cancer cell line with microsatellite instability (MSI), designated OCUM-7. ... We report on the establishment of a new scirrhous gastric cancer cell line with microsatellite instability (MSI), designated OCUM-7. This cell line was derived from a primary scirrhous...
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www.medscape.com/medline/abstract/15254696
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What Does Microsatellite Instability Have to Do With HNPCC? ... When Is Microsatellite Instability Testing Appropriate? ... Mutations in genes that repair damaged DNA cause regions called microsatellites to get longer or shorter, a phenomenon that scientists call microsatellite instability (MSI).
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www.genetichealth.com/CRC_HNPCC_Microsatellite_Instabil...
www.genetichealth.com/CRC_HNPCC_Microsatellite_Instability_Testing.shtml
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A change that occurs in the DNA of certain cells (such as tumor cells) in which the number of repeats of microsatellites (short, repeated sequences of DNA) is different than The cause of microsatellite instability may be a defect in the ability to repair mistakes made when DNA is copied in the cell. Also called MSI.
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www.cancer.gov/dictionary/?CdrID=285933
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Key Words: glandular cancer • repair genes • microsatellite instability ... For ovarian cancers, microsatellite instability ranges is detected in 10%–20% of examined cases (75, 76) and in up to 50% of cell lines originating from this type of cancers (77). These observations suggest that the instability might be common...
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www.ebmonline.org/cgi/content/full/227/8/579
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Human bronchial epithelial cells malignantly transformed by hexavalent chromium exhibit an aneuploid phenotype but no microsatellite instability.
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www.novoseek.com/SearchAction.action?query=microsatelli...
www.novoseek.com/SearchAction.action?query=microsatellite+instability&corpus=MEDLINE&criterion=1
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