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Given TNT’s high specificity for necrotic tumor cells, TNT antibodies make excellent delivery molecules for a wide variety of anti-cancer killing agents. To date, the TNT technology platform has been used to deliver various killing agents such as radioactive isotopes, cytokines, chemokines and liposomes to solid tumors.
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www.news-medical.net/news/2004/03/25/136.aspx
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Here, we investigated whether exposure to apoptotic or necrotic cells affected DC maturation. We found that immature DCs efficiently phagocytose a variety of apoptotic and necrotic tumor cells. However, only exposure to the latter induces maturation.
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www.medscape.com/medline/abstract/10662788
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DWI shows high signal intensity in most cases of pyogenic abscesses and low signal intensity in most cases of cystic or necrotic tumors. MR spectroscopy shows characteristic metabolites in pyogenic abscesses, distinct from those in cystic or necrotic tumors.
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www.medscape.com/medline/abstract/15508936
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The tumors were considered necrotic only when necroses were macroscopically remarkable and the distinction between necroses and non-necrotic tumor cut surfaces was grossly apparent. Diffuse friability of the papillary tumor caused by long ischemic time or delayed fixation was considered as degeneration, not necrosis.
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jjco.oxfordjournals.org/cgi/content/full/hyl123v1
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Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells. ... Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells...Consequences of cell death: exposure to necrotic...
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www.ncbi.nlm.nih.gov/pubmed/10662788
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Here, we show that standard procedures to induce apoptosis by UVB irradiation unequivocally result in a mixed population of viable, apoptotic, and necrotic tumor cells, necessitating additional purification.
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cancerres.aacrjournals.org/cgi/content/full/61/22/8105
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Necrotic Tumor Cell Death In Vivo Impairs Tumor-Specific Immune Responses1 ... Adoptive transfer of lymphocytes from mice with apoptotic tumors into tumor-challenged mice resulted in a significant tumor protection, which was absent when splenocytes were transferred from mice with necrotic tumors.
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www.jimmunol.org/cgi/content/abstract/178/3/1573
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Necrotic Tumor Cell Death In Vivo Impairs Tumor-Specific Immune Responses; J. Immunol., February 1, 2007; 178(3): 1573 - 1580. [Abstract] [Full Text] [PDF]; ... T Cell Immunity Induced by Live, Necrotic, and Apoptotic Tumor Cells; J. Immunol., July 15, 2004; 173(2): 1012 - 1022. [Abstract] [Full Text] [PDF];
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www.jimmunol.org/cgi/content/abstract/163/4/1730
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Other factors that may be responsible for the lack of self-immunization through necrotic tumor lysates may exist; however, the two factors of quantity and location of necrosis, identified here, are important.
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www.cancerimmunity.org/v3p4/030604.htm
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