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With a nonsense mutation, the new nucleotide changes a codon that specified an amino acid to one of the STOP codons (TAA, TAG, or TGA). Therefore, translation of the messenger RNA transcribed from this mutant gene will stop prematurely.
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users.rcn.com/jkimball.ma.ultranet/BiologyPages/M/Mutat...
users.rcn.com/jkimball.ma.ultranet/BiologyPages/M/Mutations.html
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Genetic analysis of the pedigree detected a novel EYA1 heterozygous nonsense mutation in affected family members but not in unaffected family members or a random DNA panel.
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www.medscape.com/medline/abstract/16813606
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A novel autosomal recessive mutation arose spontaneously in a breeding colony of Chinese Kunming mice. ... Sequencing the complete cDNA of the hairless gene identified two polymorphisms and a homozygous transition for a G --> A at nucleotide position 3110 (exon 12) leading to the substitution of tryptophan by a nonsense codon,
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www.medscape.com/medline/abstract/15955095
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Brief and Straightforward Guide: What Is a Nonsense Mutation? ... A nonsense mutation is a single base substitution, or point mutation. When a nonsense mutation occurs, only one base is changed in the DNA strand.
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www.wisegeek.com/what-is-a-nonsense-mutation.htm
www.wisegeek.com/what-is-a-nonsense-mutation.htm
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A nonsense mutation is a genetic mutation in a DNA sequence that results in a shorter, unfinished protein product. ... A nonsense mutation is a genetic mutation in a DNA sequence that results in a shorter, unfinished protein product. DNA is a chain of many smaller molecules called nucleotides.
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www.nature.com/scitable/definition/nonsense-mutation-22...
www.nature.com/scitable/definition/nonsense-mutation-228
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In this example, the nucleotide cytosine is replaced by thymine in the DNA code, signaling the cell to shorten the protein. ... What kinds of gene mutations are possible? ... Handbook > Handbook Illustrations >
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ghr.nlm.nih.gov/handbook/illustrations/nonsense
ghr.nlm.nih.gov/handbook/illustrations/nonsense
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In fact, it is fair to say that, without mutation, life itself could not exist. In this lecture we will broadly discuss mechanisms by which ... Though nonsense mutations tend to be the product of point mutations, it is worth noting that frameshift mutations also tend to lead to the creation of multiple stop codons.
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www.mansfield.ohio-state.edu/~sabedon/biol1075.htm
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Easy-to-use, talking glossary of genetic terms, produced by the National Human Genome Research Institute. ... Dr. Richard Morgan, formerly of the National Human Genome Research Institute's Clinical Gene Therapy Branch, defines nonsense mutation. ... Pronounciation of nonsense mutation...
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www.genome.gov/glossary.cfm?key=nonsense%20mutation
www.genome.gov/glossary.cfm?key=nonsense%20mutation
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