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Osseous metastases pose a formidable health threat to patients with metastatic disease, putting them at risk for pain, marrow crowding, fracture, and other sequelae. Treatments directed against bone disease have the potential both to palliate pain and to increase survival.
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theoncologist.alphamedpress.org/cgi/content/abstract/8/...
theoncologist.alphamedpress.org/cgi/content/abstract/8/2/161
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Hortobagyi GN, Libshitz HI, Seabold JE. Osseous metastases of breast cancer. Clinical, biochemical, radiographic, and scintigraphic evaluation of response to therapy. Cancer. Feb 1 1984;53(3):577-82. [Medline].
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emedicine.medscape.com/article/387840-overview
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Jul 25, 2007 ... Once it has progressed into osseous metastases, the prognosis is poor. ... Nine patients sustained multiple osseous metastases and most ...
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www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1945...
www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1945025
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The Medscape Journal ... Allergy & Clinical Immunology ... Diabetes & Endocrinology...
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www.medscape.com/medline/abstract/5401553
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The Medscape Journal ... Allergy & Clinical Immunology ... Diabetes & Endocrinology...
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www.medscape.com/medline/abstract/5939442
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TABLE I. Anatomic Distribution of Osseous Metastases: Pretherapy. Detection by X-Rays and Scans ..... of osseous metastases. Edmonson and associates” showed ...
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doi.wiley.com/10.1002/1097-0142(19840201)53:3%3C577::AI...
doi.wiley.com/10.1002/1097-0142(19840201)53:3%3C577::AID-CNCR2820530335%3E3.0.CO;2-U
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Several sequelae occur as a result of osseous metastases and resulting bone pain can lead to significant debilitation. Pain associated with osseous metastasis is thought to be distinct from neuropathic or inflammatory pain.
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jnm.snmjournals.org/cgi/content/abstract/45/8/1358
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14 Cases of Osseous Metastases from Colonic and Rectal Primary Cancers." Site and Interval to Onset of Osseous Metastases, Treatment and Survival ...
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www.springerlink.com/index/NG75T7804J877727.pdf
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Mertens WC, Filipczak LA, Ben-Josef E, Davis LP, Porter AT. Systemic bone-seeking radionuclides for palliation of painful osseous metastases: current concepts. CA Cancer J Clin.1998; 48(6):361-374.
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www.mcw.edu/fastFact/ff_116.htm
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