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Pepsins are synthesized as inactive pre-proenzymes, consisting of a signal peptide, activation peptide and active enzyme. The signal peptide is cleaved as the protein is inserted into endoplasmic reticulum and the resulting proenzyme - pepsinogen - is transported to the Golgi and condensed into secretory granules.
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www.vivo.colostate.edu/hbooks/pathphys/digestion/stomac...
www.vivo.colostate.edu/hbooks/pathphys/digestion/stomach/pepsin.html
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Below pH 3, this second order process was studied by observing the initial rate of pepsinogen activation in the presence of pepsin. ...
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www.jbc.org/content/247/14/4628.abstract
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Intramolecular pepsinogen activation is inhibited either by pepstatin, a potent pepsin inhibitor, or by purified globin from hemoglobin, a good pepsin ...
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www.jbc.org/cgi/content/abstract/251/22/7095
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Studies on the irreversible step of pepsinogen activation. ... A kinetic analysis of the activation of pig pepsinogen by chemical and physical techniques. ...
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www.ncbi.nlm.nih.gov/pmc/articles/PMC1219805/
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Mechanism of intramolecular activation of pepsinogen. Evidence for an intermediate delta and the involvement of the active site of pepsin in the intramolecular activation of pepsinogen. ... Early events of pepsinogen activation.
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www.ncbi.nlm.nih.gov/pubmed/3707916
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P!g pepsinogen activation at pH 3 and below is initiated by ... the rate of activation for a spin-labeled pepsinogen (Twining et al., 1981). ...
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pubs.acs.org/doi/abs/10.1021/bi00307a031
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ABSTRACT: The bond cleavage step of pepsinogen activation has been investigated .... I Although the title of this paper uses "pepsinogen activation" because ...
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pubs.acs.org/doi/abs/10.1021/bi00432a040
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and activates pepsinogen. Pepsinogen is an enzyme that starts protein digestion. Pepsinogen is produced in cells that line the gastric pits. It is activated by cleaving off a portion of the molecule, producing the enzyme pepsin that splits off fragments of peptides from a protein molecule during digestion in the stomach.
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www.emc.maricopa.edu/faculty/farabee/BIOBK/BioBookDIGES...
www.emc.maricopa.edu/faculty/farabee/BIOBK/BioBookDIGEST.html
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Adv Exp Med Biol. 1998;436:245-52. Unique Identifier : AIDSLINE MED/98221997; Koelsch G; Loy J; Lin X; Tang J; Protein Studies Program, Oklahoma Medical Research Foundation,; University of Oklahoma Health Sciences Center, ... AEGiS presents published material, ... It is often presented in summary or aggregate form. It is not...
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www.aegis.com/aidsline/1998/aug/M9880712.html
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