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Physical dependence - Wikipedia, the free encyclopedia
Physical dependence refers to a state resulting from chronic use of a drug that has produced tolerance and where negative physical symptoms of withdrawal result from abrupt discontinuation or dosage ...
en.wikipedia.org/wiki/Physical_dependence |
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Addiction - Wikipedia, the free encyclopedia
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A condition in which a person takes a drug over time, and unpleasant physical symptoms occur if the drug is suddenly stopped or taken in smaller doses.
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Recreational drugs information resource for mobile devices ... Physical dependence means the body gets used to the drug, it needs more and more of it to accomplish the same effect. Finally, the drug is merely used to counteract the withdrawal symptoms that appear when no drugs are being taken.
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Thakore J, Dinan TG. Physical dependence following zopiclone usage: a case report. Hum Psychopharmacol 1992;7:143-5. ... Physical dependence on zopiclone Sudip Sikdar, Oyedeji Ayonrinde, and Elizabeth Sampson; BMJ 1998 317: 146. [Extract] [Full Text]
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CONCLUSIONS: Memantine attenuated the expression of opioid physical dependence in humans, indicating that glutamatergic neurotransmission at the NMDA receptor site contributes to the maintenance of opioid dependence.
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