Prophylactic cranial irradiation is now known to improve survival to a significant degree in small-cell lung cancer (SCLC) patients; this is in addition to its established role in preventing the disabling symptoms of brain metastases.
theoncologist.alphamedpress.org/cgi/content/full/5/4/29... theoncologist.alphamedpress.org/cgi/content/full/5/4/293
Information on prophylactic cranial irradiation from MedicineWorld.Org. Your gateway to medical information. Information for patients, resources for physicians. ... Yet the role of prophylactic cranial irradiation is controversial. Most studies have suggested that preventative brain irradiation, usually known as...
medicineworld.org/cancer/lung/small-cell/prophylactic-c... medicineworld.org/cancer/lung/small-cell/prophylactic-cranial-irradiation.html
Prophylactic cranial irradiation after chemotherapy significantly reduces the risk of brain metastasis and doubles one-year survival in small-cell lung cancer, according to the results of the multicenter phase III randomized trial. ... "I expect prophylactic cranial irradiation will be taken up quickly in the US,
www.sciencedaily.com/releases/2007/08/070816124110.htm
Original Article from The New England Journal of Medicine -- Prophylactic Cranial Irradiation for Patients with Small-Cell Lung Cancer in Complete Remission ... Prophylactic Cranial Irradiation for Patients with Small-Cell Lung Cancer in Complete Remissio...
content.nejm.org/cgi/content/short/341/7/476
Original Article from The New England Journal of Medicine -- Prophylactic Cranial Irradiation in Extensive Small-Cell Lung Cancer ... Prophylactic Cranial Irradiation in Extensive Small-Cell Lung Cance...
content.nejm.org/cgi/content/abstract/357/7/664
June 6, 2007 (Chicago) — In patients with advanced small-cell lung cancer (SCLC) who responded to chemotherapy, administration of prophylactic cranial irradiation significantly reduced the risk of developing brain metastases and significantly improved overall survival.
www.medscape.com/viewarticle/557816
: Patients who received prophylactic cranial irradiation had fewer brain metastases but no advantage in overall or disease-free survival and greater memory loss after the therapy. ... Prophylactic Cranial Irradiation in Lung Cancer Patients Shows Definitive Benefits...
www.medscape.com/viewarticle/706930
The Prophylactic Cranial Irradiation Overview Collaborative Group ... Prophylactic cranial irradiation improves survival rate of patients with small-cell lung cancer in complete remission ... This review found that prophylactic cranial irradiation given to patients in complete remission after initial treatment improves survival.
www.cochrane.org/reviews/en/ab002805.html
A systematic review of the literature was carried out to determine the role of prophylactic cranial irradiation (PCI) in small cell lung cancer (SCLC) .
www.biomedcentral.com/1471-2407/1/5&y=024D07BF0499EB9E&... www.biomedcentral.com/1471-2407/1/5&y=024D07BF0499EB9E&i=487&c=9103&q=02%255ESSHPM%255BL7%257Dm~vq%253F%257C~q%257Czm%253F%257Czss%253Flr~ss6&e=utf-8&r=9&d=wownrm-en-us&n=EB545H3EB5J42TLI&s=2&t=&m=41665D54&x=013768C89A3C6996
BACKGROUND: The optimum dose of prophylactic cranial irradiation (PCI) for limited-stage small-cell lung cancer (SCLC) is unknown. A meta-analysis suggested that the incidence of brain metastases might be reduced with higher PCI doses.
www.ncbi.nlm.nih.gov/pubmed/19386548