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This is why PIs can affect the metabolism of other protease inhibitors and other drugs for different illnesses. The protease inhibitor that has the strongest effect on these enzymes is Norvir.
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www.thebody.com/content/art880.html
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In March, the Food and Drug Administration (FDA) approved the second and third of a new class of drugs called protease inhibitors. Protease inhibitors are compounds that block the protease enzyme of HIV, thereby preventing the production of infectious viral particles.
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www.aegis.com/factshts/niaid/1996/niaid96_fact_sheet_pr...
www.aegis.com/factshts/niaid/1996/niaid96_fact_sheet_protease.html
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Roche has announced an expanded access scheme for its protease inhibitor, saquinavir. The drug will be available from 1st December to people in the UK who have failed on other anti-retroviral drugs, ... Other protease inhibitors currently in development will not be so easy to access. This is because they are very difficult...
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www.aegis.com/pubs/atu/1995/ATU3503.html
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Protease inhibitors can affect the absorption of other drugs by the body. These are called drug interactions. Your health care provider should go over any potential drug interactions with you when starting a protease inhibitor.
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www.aegis.org/factshts/network/simple/protease.html
www.aegis.org/factshts/network/simple/protease.html
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The Medscape Journal ... HIV Protease Inhibitors [chemistry] [therapeutic use] ... 0 (HIV Protease Inhibitors)
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www.medscape.com/medline/abstract/9612066
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Protease inhibitors are drugs that are commonly used in the therapy of people living with HIV infection. ... Protease inhibitors are drugs that are commonly used in the therapy of people living with HIV infection. These drugs are commonly used in combination and act by inhibiting viral protease, blocking viral replication.
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www.medscape.com/medline/abstract/12422251
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When HIV infects a CD4 cell in a person's body, it copies its own genetic code into the cell's DNA. The CD4 cell is then "programmed" to make new HIV genetic material and HIV proteins. The proteins must be cut up by the HIV protea...
http://www.aidsmeds.com/PIs.htm
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Many drugs, including protease inhibitors, are excreted through the CP450 system. Other drugs stimulate or speed up the action of the CP450 system. If the activity of an enzyme is decreased, drugs requiring that enzyme for metabolism will have increased blood concentrations, effects and toxicities.
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www.sfaf.org/treatment/beta/b34/b34piint.html
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