Amyloid precursor protein - Wikipedia, the free encyclopedia
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Amyloid precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. Its primary function is not known, though it has been implicated...
en.wikipedia.org/wiki/Amyloid_precursor_protein
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In Alzheimer's disease, beta amyloid protein is deposited in the walls of vessels and in extracellular parenchyma in the brain. 140 This amyloid protein has been solubilized, its sequence determined,39,75 and the gene for it cloned.
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www.dmso.org/articles/alzheimers/alzheim2.htm
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The depletion of glycosphingolipids markedly reduced the secretion of endogenous beta-amyloid precursor protein in different cell types, including human neuroblastoma SH-SY5Y cells. Importantly, secretion of amyloid beta-peptides was also strongly decreased by inhibition of glycosphingolipid biosynthesis.
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www.medscape.com/medline/abstract/15923191
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It is well established that the rate of formation of fibrils by amyloidogenic proteins is enhanced by the addition of preformed fibrils, a phenomenon known as seeding. ... In addition, it is consistent with the observation of a single dominant type of protein in the deposits associated with each form of amyloid disease.
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www.medscape.com/medline/abstract/15215533
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However, only within the past 20 years have physicians understood the specific make-up and structure of amyloid protein. Although amyloidosis is not cancer, it is very serious. It may be disabling or life threatening.
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www.amyloidosis.org/whatisit.asp
www.amyloidosis.org/whatisit.asp
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Scientists have found that the amyloid-beta protein, currently the target of Alzheimer's drug research, is essential for normal information transfer through nerve cell networks in the brain. ... Amyloid Beta Protein Gets Bum Rap (Nov. 10, 2009) — While too much amyloid beta protein in the brain is linked to the...
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www.sciencedaily.com/releases/2009/11/091123114813.htm
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Amyloid protein exists in two forms, soluble and fibrous. It is secreted by neurons in the soluble form, diffuses in the soluble form and can be changed to a fibrous form depending on its local concentration, and on the interaction between the soluble and fibrous forms.
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www.math.ubc.ca/~ais/website/formulation/amyloid.html
www.math.ubc.ca/~ais/website/formulation/amyloid.html
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Amyloid The Journal of Protein Folding Disorders. Amyloid: International journal of Experimental and Clinical Investigation is moving! ...
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www.informaworld.com/1350-6129
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Recent knowledge supports the idea that early protein aggregates share basic structural features and are responsible for cytotoxicity underlying neurodegeneration; in most cases, early aggregate cytotoxicity apparently proceeds through similar molecular mechanisms and results in similar biochemical modifications.
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nro.sagepub.com/cgi/content/abstract/13/5/519
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